Predicting RNA structures and functions by artificial intelligence

J Zhang, M Lang, Y Zhou, Y Zhang - Trends in Genetics, 2024 - cell.com
RNA functions by interacting with its intended targets structurally. However, due to the
dynamic nature of RNA molecules, RNA structures are difficult to determine experimentally …

A comprehensive survey of foundation models in medicine

W Khan, S Leem, KB See, JK Wong… - IEEE Reviews in …, 2025 - ieeexplore.ieee.org
Foundation models (FMs) are large-scale deeplearning models that are developed using
large datasets and self-supervised learning methods. These models serve as a base for …

Wfold: A new method for predicting RNA secondary structure with deep learning

Y Yuan, E Yang, R Zhang - Computers in Biology and Medicine, 2024 - Elsevier
Precise estimations of RNA secondary structures have the potential to reveal the various
roles that non-coding RNAs play in regulating cellular activity. However, the mainstay of …

[HTML][HTML] mRNA vaccine sequence and structure design and optimization: Advances and challenges

L Jin, Y Zhou, S Zhang, SJ Chen - Journal of Biological Chemistry, 2024 - Elsevier
Messenger RNA (mRNA) vaccines have emerged as a powerful tool against communicable
diseases and cancers, as demonstrated by their huge success during the coronavirus …

Machine Learning in RNA Structure Prediction: Advances and Challenges

S Zhang, J Li, SJ Chen - Biophysical Journal, 2024 - cell.com
RNA molecules play a crucial role in various biological processes, with their functionality
closely tied to their structures. The remarkable advancements in machine learning …

Robust RNA secondary structure prediction with a mixture of deep learning and physics-based experts

X Qiu - Biology Methods and Protocols, 2025 - academic.oup.com
A mixture-of-experts (MoE) approach has been developed to mitigate the poor out-of-
distribution (OOD) generalization of deep learning (DL) models for single-sequence-based …

Deciphering RNA Secondary Structure Prediction: A Probabilistic K-Rook Matching Perspective

C Tan, Z Gao, CAO Hanqun, X Chen, G Wang… - Forty-first International … - openreview.net
The secondary structure of ribonucleic acid (RNA) is more stable and accessible in the cell
than its tertiary structure, making it essential for functional prediction. Although deep learning …

RNA-Protein Interaction Classification via Sequence Embeddings

D Matus, F Runge, JKH Franke, L Gerne, M Uhl… - bioRxiv, 2024 - biorxiv.org
RNA-protein interactions (RPI) are ubiquitous in cellular organisms and essential for gene
regulation. In particular, protein interactions with non-coding RNAs (ncRNAs) play a critical …

Towards Generative RNA Design With Tertiary Interactions

S Patil, F Runge, JKH Franke, F Hutter - bioRxiv, 2024 - biorxiv.org
The design of RNAs that fulfill desired functions is one of the major challenges in
computational biology. The function of an RNA molecule depends on its structure and a …

[PDF][PDF] RNA-Protein Interaction Prediction via Sequence Embeddings

D Matus, F Runge, JKH Franke, L Gerne, M Uhl… - ml.informatik.uni-freiburg.de
RNA-protein interactions (RPI) are ubiquitous in cellular organisms and essential for gene
regulation. In particular, protein interactions with non-coding RNAs (ncRNAs) play a critical …