Organs-on-chip (OoC), often referred to as microphysiological systems (MPS), are advanced
in vitro tools able to replicate essential functions of human organs. Owing to their …

Here, the scientific and patent literature on the activities of purified natural compounds has
been reviewed, with the aim of assessing their suitability as anthelmintic drug discovery …

Microfluidic organ-on-a-chip technology aims to replace animal toxicity testing, but thus far
has demonstrated few advantages over traditional methods. Mitochondrial dysfunction plays …

Accumulating evidence indicates that mitochondrial dysfunction and oxidative stress play a
pivotal role in the initiation and progression of nonalcoholic fatty liver disease (NAFLD). In …

Reactive sulfur species (RSS) include sulfur dioxide (SO 2) and various biothiols, such as
hydrogen sulfide (H 2 S), glutathione (GSH), cysteine (Cys), and homocysteine (Hcy). These …

Acetochlor is a high-volume herbicide used on a global scale and toxicity assessments are
needed to define its potential for adverse effects in wildlife and humans. This study was …

Current pre-clinical models to evaluate drug safety during the drug development process
(DDP) mainly rely on traditional two-dimensional cell cultures, considered too simplistic and …

Oxidative stress and mitochondrial dysfunction are leading mechanisms that play a crucial
role in the progression of Parkinson's disease (PD). Tinospora cordifolia shows a wide …

A new chromone-appended Cu (II) drug entity (1) was designed and synthesized as a
potential anticancer chemotherapeutic agent. The structural elucidation was carried out …

Background: A central challenge in toxicity testing is the large number of chemicals in
commerce that lack toxicological assessment. In response, the Tox21 program is re-focusing …