Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Pacemaking is a basic physiological process, and the cellular mechanisms involved in this
function have always attracted the keen attention of investigators. The “funny”(I f) current …

Recent studies provide increasing evidence that postnatal neovascularization involves bone
marrow–derived circulating endothelial progenitor cells (EPCs). The regulation of EPCs in …

▪ Abstract Hyperpolarization-activated cation currents, termed If, Ih, or Iq, were initially
discovered in heart and nerve cells over 20 years ago. These currents contribute to a wide …

The quest to determine how precise neural activity patterns mediate computation, behavior,
and pathology would be greatly aided by a set of tools for reliably activating and inactivating …

Resting heart rate is associated with cardiovascular and all-cause mortality, and the
mortality benefit of some cardiovascular drugs seems to be related in part to their heart rate …

About 50 years ago, pioneering work initiated by Silvio Weidmann and others applied the
Hodgkin-Huxley formalism of membrane excitation to interpret the cardiac electrical activity …

It is now over 100years since the discovery of the cardiac conduction system, consisting of
three main parts, the sinus node, the atrioventricular node and the His–Purkinje system. The …

The hyperpolarization-activated cation current (termed If, Ih, or Iq) plays a key role in the
initiation and modulation of cardiac and neuronal pacemaker depolarizations. Recently, the …

Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …