Translational precision medicine: an industry perspective
In the era of precision medicine, digital technologies and artificial intelligence, drug
discovery and development face unprecedented opportunities for product and business …
discovery and development face unprecedented opportunities for product and business …
Digital health technology for non-motor symptoms in people with Parkinson's disease: Futile or future?
Introduction There is an ongoing digital revolution in the field of Parkinson's disease (PD) for
the objective measurement of motor aspects, to be used in clinical trials and possibly …
the objective measurement of motor aspects, to be used in clinical trials and possibly …
Digital literacy and online political behavior
Digital literacy is receiving increased scholarly attention as a potential explanatory factor in
the spread of misinformation and other online pathologies. As a concept, however, it …
the spread of misinformation and other online pathologies. As a concept, however, it …
Empowering clinical research in a decentralized world
The COVID-19 pandemic has been a catalyst for the implementation of decentralized clinical
trials (DCTs) enabled by digital health technologies (DHTs) in the field while curtailing in …
trials (DCTs) enabled by digital health technologies (DHTs) in the field while curtailing in …
[HTML][HTML] Precompetitive consensus building to facilitate the use of digital health technologies to support Parkinson disease drug development through regulatory …
Innovative tools are urgently needed to accelerate the evaluation and subsequent approval
of novel treatments that may slow, halt, or reverse the relentless progression of Parkinson …
of novel treatments that may slow, halt, or reverse the relentless progression of Parkinson …
How much evidence is enough? research sponsor experiences seeking regulatory acceptance of digital health technology-derived endpoints
B Perry, L Kehoe, T Swezey, Q Le Masne… - Digital …, 2023 - karger.com
Abstract Introduction: Digital health technologies (DHTs) provide opportunities for real-time
data collection and assessment of patient function. However, use of DHT-derived endpoints …
data collection and assessment of patient function. However, use of DHT-derived endpoints …
Development and technical validation of a smartphone‐based pediatric cough detection algorithm
MD Kruizinga, A Zhuparris, E Dessing… - Pediatric …, 2022 - Wiley Online Library
Introduction Coughing is a common symptom in pediatric lung disease and cough frequency
has been shown to be correlated to disease activity in several conditions. Automated cough …
has been shown to be correlated to disease activity in several conditions. Automated cough …
[HTML][HTML] Why language matters in digital endpoint development: harmonized terminology as a key prerequisite for evidence generation
L Leyens, CA Northcott, L Maloney, M McCarthy… - Digital …, 2024 - karger.com
Background: Developments in the field of digital measures and digitally derived endpoints
demand greater attention on globally aligned approaches to enhance digital measure …
demand greater attention on globally aligned approaches to enhance digital measure …
Towards remote monitoring in pediatric care and clinical trials—Tolerability, repeatability and reference values of candidate digital endpoints derived from physical …
MD Kruizinga, N Heide, A Moll, A Zhuparris, Y Yavuz… - PloS one, 2021 - journals.plos.org
Background Digital devices and wearables allow for the measurement of a wide range of
health-related parameters in a non-invasive manner, which may be particularly valuable in …
health-related parameters in a non-invasive manner, which may be particularly valuable in …
A multimodal dataset of real world mobility activities in Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disorder characterised by motor symptoms
such as gait dysfunction and postural instability. Technological tools to continuously monitor …
such as gait dysfunction and postural instability. Technological tools to continuously monitor …