Click chemistry-aided drug discovery: A retrospective and prospective outlook

R Zhao, J Zhu, X Jiang, R Bai - European Journal of Medicinal Chemistry, 2024 - Elsevier
Click chemistry has emerged as a valuable tool for rapid compound synthesis, presenting
notable advantages and convenience in the exploration of potential drug candidates. In …

Design, classification, and adverse effects of NSAIDs: A review on recent advancements

M Arfeen, A Srivastava, N Srivastava, RA Khan… - Bioorganic & Medicinal …, 2024 - Elsevier
Inflammation is a hallmark of many diseases, including cancer, neurodegenerative diseases
like Alzheimer's, type II diabetes, rheumatoid arthritis, and asthma. Nonsteroidal anti …

[HTML][HTML] Indole compounds in oncology: therapeutic potential and mechanistic insights

SM Hassan, A Farid, SS Panda, MS Bekheit, H Dinkins… - Pharmaceuticals, 2024 - mdpi.com
Cancer remains a formidable global health challenge, with current treatment modalities such
as chemotherapy, radiotherapy, surgery, and targeted therapy often hindered by low efficacy …

Indole-based compounds as potential drug candidates for SARS-CoV-2

AS Girgis, SS Panda, BM Kariuki, MS Bekheit… - Molecules, 2023 - mdpi.com
The COVID-19 pandemic has posed a significant threat to society in recent times,
endangering human health, life, and economic well-being. The disease quickly spreads due …

A one-pot photocatalytic triazole-based linkerology for PROTACs

J Liu, Y Deng, J Yin, J Ji, C Guan, X Chen, X Wu… - Cell Reports Physical …, 2024 - cell.com
Proteolysis-targeting chimeras (PROTACs) are a powerful approach for targeted protein
degradation. One of the current bottlenecks for developing PROTACs is the lack of an …

Molecular hybridization of alkaloids using 1, 2, 3-triazole-based click chemistry

D Buchanan, AM Pham, SK Singh, SS Panda - Molecules, 2023 - mdpi.com
Alkaloids found in multiple species, known as 'driver species', are more likely to be included
in early-stage drug development due to their high biodiversity compared to rare alkaloids …

Tailored quinoline hybrids as promising COX-2/15-LOX dual inhibitors endowed with diverse safety profile: Design, synthesis, SAR, and histopathological study

ME Hegazy, ES Taher, AH Ghiaty, AH Bayoumi - Bioorganic Chemistry, 2024 - Elsevier
Complications of the worldwide use of non-steroidal anti-inflammatory drugs (NSAIDs)
sparked scientists to design novel harmless alternatives as an urgent need. So, a unique …

Antineoplastic indole-containing compounds with potential VEGFR inhibitory properties

DR Aboshouk, MA Youssef, MS Bekheit, AR Hamed… - RSC …, 2024 - pubs.rsc.org
Cancer is one of the most significant health challenges worldwide. Various techniques, tools
and therapeutics/materials have been developed in the last few decades for the treatment of …

Effect of felodipine on indomethacin-induced gastric ulcers in rats

N Akbaş, B Süleyman, R Mammadov… - Experimental …, 2023 - jstage.jst.go.jp
Felodipine is a calcium channel blocker with antioxidant and anti-inflammatory properties.
Researchers have stated that oxidative stress and inflammation also play a role in the …

Novel isatin conjugates endowed with analgesic and anti-inflammatory properties: design, synthesis and biological evaluation

LVD Brown, AS Girgis, S Patel, N Samir… - Future Medicinal …, 2024 - Taylor & Francis
Aims This study aimed to develop novel molecular hybrid conjugates integrating isatin,
rhodanine, and phthalimide pharmacophores to create effective analgesic and anti …