Clear cell renal cell carcinoma ontogeny and mechanisms of lethality
The molecular features that define clear cell renal cell carcinoma (ccRCC) initiation and
progression are being increasingly defined. The TRACERx Renal studies and others that …
progression are being increasingly defined. The TRACERx Renal studies and others that …
Sarcomatoid renal cell carcinoma: biology, natural history and management
Sarcomatoid dedifferentiation is an uncommon feature that can occur in most histological
subtypes of renal cell carcinomas (RCCs) and carries a decidedly poor prognosis …
subtypes of renal cell carcinomas (RCCs) and carries a decidedly poor prognosis …
[HTML][HTML] New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia
K Trpkov, O Hes, SR Williamson, AJ Adeniran… - Modern Pathology, 2021 - Elsevier
Abstract The Genitourinary Pathology Society (GUPS) reviewed recent advances in renal
neoplasia, particularly post-2016 World Health Organization (WHO) classification, to provide …
neoplasia, particularly post-2016 World Health Organization (WHO) classification, to provide …
CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas
JA Flores-Toro, D Luo, A Gopinath… - Proceedings of the …, 2020 - National Acad Sciences
Immunotherapy directed at the PD-L1/PD-1 axis has produced treatment advances in
various human cancers. Unfortunately, progress has not extended to glioblastoma (GBM) …
various human cancers. Unfortunately, progress has not extended to glioblastoma (GBM) …
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma
Z Bakouny, DA Braun, SA Shukla, W Pan, X Gao… - Nature …, 2021 - nature.com
Sarcomatoid and rhabdoid (S/R) renal cell carcinoma (RCC) are highly aggressive tumors
with limited molecular and clinical characterization. Emerging evidence suggests immune …
with limited molecular and clinical characterization. Emerging evidence suggests immune …
[HTML][HTML] Long-term outcomes with nivolumab plus ipilimumab versus sunitinib in first-line treatment of patients with advanced sarcomatoid renal cell carcinoma
Background Patients with advanced renal cell carcinoma with sarcomatoid features (sRCC)
have a poor prognosis and limited therapeutic options. First-line nivolumab plus ipilimumab …
have a poor prognosis and limited therapeutic options. First-line nivolumab plus ipilimumab …
[HTML][HTML] Hexokinase 3 dysfunction promotes tumorigenesis and immune escape by upregulating monocyte/macrophage infiltration into the clear cell renal cell …
W Xu, WR Liu, Y Xu, X Tian, A Anwaier… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Purpose: This study aimed to identify the potential prognostic role of HK3 and provide clues
about glycolysis and the microenvironmental characteristics of ccRCC. Methods: Based on …
about glycolysis and the microenvironmental characteristics of ccRCC. Methods: Based on …
[HTML][HTML] HHLA2 and PD-L1 co-expression predicts poor prognosis in patients with clear cell renal cell carcinoma
QH Zhou, KW Li, X Chen, HX He, SM Peng… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Although clear cell renal cell carcinoma (ccRCC) is well known as a highly
immunogenic tumor, only a small subset of patients could benefit from current …
immunogenic tumor, only a small subset of patients could benefit from current …
Quantitative analysis of immune infiltrates in primary melanoma
Novel methods to analyze the tumor microenvironment (TME) are urgently needed to stratify
melanoma patients for adjuvant immunotherapy. Tumor-infiltrating lymphocyte (TIL) …
melanoma patients for adjuvant immunotherapy. Tumor-infiltrating lymphocyte (TIL) …
Calpain2 Upregulation Regulates EMT-Mediated Pancreatic Cancer Metastasis via the Wnt/β-Catenin Signaling Pathway
X Peng, R Yang, J Song, X Wang, W Dong - Frontiers in medicine, 2022 - frontiersin.org
Calpains2 (CAPN2) is a calcium-dependent, non-lysosomal cysteine protease that plays
critical roles in normal cellular functions and pathological processes, including …
critical roles in normal cellular functions and pathological processes, including …