Leveraging large-scale genetics of PTSD and cardiovascular disease to demonstrate robust shared risk and improve risk prediction accuracy

AV Seligowski, B Misganaw, LA Duffy… - American Journal of …, 2022 - Am Psychiatric Assoc
Objective: Individuals with posttraumatic stress disorder (PTSD) are significantly more likely
to be diagnosed with cardiovascular disease (CVD)(eg, myocardial infarction, stroke). The …

PTSD, immune system, and inflammation

N Pivac, B Vuic, M Sagud, G Nedic Erjavec… - … , Gut-Brain Axis and …, 2023 - Springer
Posttraumatic stress disorder (PTSD) is a severe trauma and stress-related disorder
associated with different somatic comorbidities, especially cardiovascular and metabolic …

[HTML][HTML] The underlying mechanisms by which PTSD symptoms are associated with cardiovascular health in male UK military personnel: The ADVANCE cohort study

D Dyball, AN Bennett, S Schofield, P Cullinan… - Journal of psychiatric …, 2023 - Elsevier
Abstract Post-Traumatic Stress Disorder (PTSD) has been identified as an independent risk
factor for cardiovascular disease, but the mechanisms of this relationship are not well …

New recognition of the heart–brain axis and its implication in the pathogenesis and treatment of PTSD

H Li, H Cheng, K Ding, Y Zhang, F Gao… - European Journal of …, 2024 - Wiley Online Library
Post‐traumatic stress disorder (PTSD) is a complex psychological disorder provoked by
distressing experiences, and it remains without highly effective intervention strategies. The …

From soldier's heart to shared genetic risk: PTSD and cardiovascular disease

RJ Ursano, MB Stein - American Journal of Psychiatry, 2022 - Am Psychiatric Assoc
A causal relationship of posttraumatic stress disorder (PTSD) and cardiovascular disease
(CVD) has been long postulated, and has occasionally been examined primarily …

Dog ownership may promote cardiometabolic health in US military veterans

SH Woodward, SR Baldassarri, RH Pietrzak - Scientific Reports, 2023 - nature.com
Dog ownership has been associated with reduced cardiovascular and all-cause mortality in
civilian epidemiological samples. Associations between dog ownership and cardiometabolic …

Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records

R Polimanti, FR Wendt, GA Pathak, DS Tylee… - Molecular …, 2022 - nature.com
The association between coronary artery disease (CAD) and posttraumatic stress disorder
(PTSD) contributes to the high morbidity and mortality observed for these conditions. To …

Cingulate and hippocampal subregion abnormalities in combat-exposed veterans with PTSD

PR Szeszko, LM Bierer, HN Bader, KW Chu… - Journal of affective …, 2022 - Elsevier
Background The hippocampus and cingulate gyrus are strongly interconnected brain
regions that have been implicated in the neurobiology of post-traumatic stress disorder …

Methylation of the AIM2 gene: An epigenetic mediator of PTSD‐related inflammation and neuropathology plasma biomarkers

SE Hawn, Z Neale, EJ Wolf, X Zhao… - Depression and …, 2022 - Wiley Online Library
Background Posttraumatic stress disorder (PTSD) is associated with inflammation and
various forms of chronic disease. The Absent in Melanoma 2 (AIM2) gene has been …

Dog Ownership May Promote Cardiac Health in US Military Veterans: Results from the National Health and Resilience in Veterans Study

SH Woodward, SR Baldassarri, RH Pietrzak - 2022 - researchsquare.com
Dog ownership has been associated with reduced cardiovascular and all-cause mortality in
epidemiological samples. US miliary Veterans exhibit elevated rates of cardiovascular …