The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG
lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating …

We update complementary learning systems (CLS) theory, which holds that intelligent
agents must possess two learning systems, instantiated in mammalians in neocortex and …

Cognitive faculties such as imagination, planning, and decision-making entail the ability to
represent hypothetical experience. Crucially, animal behavior in natural settings implies that …

Oxytocin receptor (Oxtr) signaling in neural circuits mediating discrimination of social stimuli
and affiliation or avoidance behavior is thought to guide social recognition. Remarkably, the …

The mechanistic operation of brain regions is often interpreted by partitioning constituent
neurons into 'cell types'. Historically, such cell types were broadly defined by their …

Hippocampal area CA2 has several features that distinguish it from CA1 and CA3, including
a unique gene expression profile, failure to display long-term potentiation and relative …

Granule cells in the dentate gyrus of the hippocampus are thought to be essential to memory
function by decorrelating overlapping input patterns (pattern separation). A second …

The mammalian hippocampus is critical for spatial information processing and episodic
memory. Its primary output cells, CA1 pyramidal cells (CA1 PCs), vary in genetics …

There has been considerable speculation regarding the function of the dentate gyrus (DG)—
a subregion of the mammalian hippocampus—in learning and memory. In this Perspective …

Classic computational theories of the mnemonic functions of the hippocampus ascribe the
processes of pattern separation to the dentate gyrus (DG) and pattern completion to the CA3 …