Aldosterone exerts profound effects on renal and cardiovascular physiology. In the kidney,
aldosterone acts to preserve electrolyte and acid-base balance in response to changes in …

In the past, it was believed that the expression of the epithelial sodium channel (ENaC) was
restricted to epithelial tissues, such as the distal nephron, airway, sweat glands, and colon …

The lungs and kidneys are pivotal organs in the regulation of body acid–base homeostasis.
In cystic fibrosis (CF), the impaired renal ability to excrete an excess amount of HCO3− into …

Background The secretin receptor (SCTR) is functionally expressed in the basolateral
membrane of the β-intercalated cells of the kidney cortical collecting duct and stimulates …

Experimental studies have shown that V-type ATPase-driven H+ secretion is dependent on
transepithelial voltage. On this basis, the “voltage hypothesis” of urinary acidification by the …

There is growing consensus that under physiological conditions, collecting duct H+
secretion is independent of epithelial Na+ channel (ENaC) activity. We have recently shown …

Our body is constantly exposed to a multitude of challenges, which could cause
disturbances to the internal milieu. An example is food intake. Food provides our body with …

Nephrotic syndrome is a pathology characterized by severe proteinuria, hypoalbuminemia,
dyslipidemia, and edema. Edema has classically been associated with an alteration of the …