Cellular senescence is a state of terminal growth arrest associated with the upregulation of
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …

Microrheology encompasses a range of methods to measure the mechanical properties of
soft materials. By characterizing the motion of embedded microscopic particles …

Background: There is a strong interest in designing new scaffolds for their potential
application in tissue engineering and regenerative medicine. The incorporation of …

Tissue engineering and regenerative medicine are pursuing clinical valid solutions to repair
and restore function of damaged tissues or organs. This can be achieved in different ways …

Macrophages (MΦ) are highly adaptable and functionally polarized cells that play a crucial
role in various physiological and pathological processes. Typically, MΦ differentiate into two …

The immune system plays a crucial role during tissue repair and wound healing processes.
Biomaterials have been leveraged to assist in this in situ tissue regeneration process to …

Biomaterials that recapitulate the native in vivo microenvironment are promising to facilitate
tissue repair and regeneration when used in combination with relevant growth factors (GFs) …

Implantation of scaffolds causes a local inflammatory response whereby the early
recruitment of neutrophils is of great importance not only for fighting the infection, but also for …

An estimated 750,000 arthroscopic knee operations are performed in the United States each
year, and many are due to a torn meniscus. Transplantation with donor tissue is the gold …

Significance: Volumetric muscle loss (VML) is caused by the loss of significant amounts of
skeletal muscle tissue. VML cannot be repaired by intrinsic regenerative processes …