It has been noticed in recent years that the unfavorable effects of the gut microbiota could
exhaust host vigor and life, yet knowledge and theory are just beginning to be established …

Among human leukocyte antigen (HLA)-associated disorders, celiac disease has an
immunopathogenesis that is particularly well understood. The condition is characterized by …

Genome-wide association studies provide a powerful means of identifying loci and genes
contributing to disease, but in many cases, the related cell types/states through which genes …

Crohn's disease (CD) is a chronic gastrointestinal disease that is increasing in prevalence
worldwide. CD is multifactorial, involving the complex interplay of genetic, immune, and …

The intimate relationship between the epithelium and immune system is crucial for
maintaining tissue homeostasis, with perturbations therein linked to autoimmune disease …

Abstract γδ T cells are important tissue-resident, innate T cells that are critical for tissue
homeostasis. γδ cells are associated with positive prognosis in most tumors; however, little …

γδ T cells represent a substantial fraction of intestinal lymphocytes at homeostasis, but they
also constitute a major lymphocyte population infiltrating colorectal cancers (CRCs); …

The unconventional T cell compartment encompasses a variety of cell subsets that straddle
the line between innate and adaptive immunity, often reside at mucosal surfaces and can …

BACKGROUND In addition to providing antimicrobial immunity, the immune system governs
numerous aspects of host physiology, in part through the coordinated action of tissue …

Celiac disease (CD) is an autoimmune disease in which intestinal inflammation is induced
by dietary gluten. The means through which gluten-specific CD4+ T cell activation …