The Na+/Ca2+ exchanger, an ion transport protein, is expressed in the plasma membrane
(PM) of virtually all animal cells. It extrudes Ca2+ in parallel with the PM ATP-driven Ca2+ …

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and
inhibit Na+/K+-ATPase. Members of this family have been in clinical use for many years for …

Containing fully authenticated data on virtually all known natural products, the" Dictionary of
Natural Products", main work, published in 1993 was the end result of over 12 years …

The search for endogenous digitalis has led to the isolation of ouabain as well as several
additional cardiotonic steroids of the cardenolide and bufadienolide type from blood …

Cardiotonic steroids (CTS), long used to treat heart failure, are endogenously produced in
mammals. Among them are the hydrophilic cardenolide ouabain and the more hydrophobic …

Excess dietary salt is a major cause of hypertension. Nevertheless, the specific mechanisms
by which salt increases arterial constriction and peripheral vascular resistance, and thereby …

Cardiac glycosides have been used for decades to treat congestive heart failure. The recent
identification of cardiotonic steroids such as ouabain, digoxin, marinobufagenin, and …

Na, K-ATPase (sodium pump; EC 3.6. 1.37) is present in the membrane of most eukaryotic
cells and controls directly or indirectly many essential cellular functions. Regulation of this …

BACKGROUND An endogenous digitalis-like compound in mammals has long been
postulated, but only recently has a substance indistinguishable from ouabain been identified …

For over three decades, renal physiology has sought a putative natriuretic hormone (third
factor) that might control the body's pool of extracellular fluid, an important determinant in …