Maturation of persistent and hyperpolarization-activated inward currents shapes the differential activation of motoneuron subtypes during postnatal development

SA Sharples, GB Miles - Elife, 2021 - elifesciences.org
The size principle underlies the orderly recruitment of motor units; however, motoneuron
size is a poor predictor of recruitment amongst functionally defined motoneuron subtypes …

How axon and dendrite branching are guided by time, energy, and spatial constraints

P Desai-Chowdhry, AB Brummer, VM Savage - Scientific reports, 2022 - nature.com
Neurons are connected by complex branching processes—axons and dendrites—that
process information for organisms to respond to their environment. Classifying neurons …

Axon initial segment geometry in relation to motoneuron excitability

TM Rotterman, DI Carrasco, SN Housley, P Nardelli… - PLoS …, 2021 - journals.plos.org
The axon initial segment (AIS) responsible for action potential initiation is a dynamic
structure that varies and changes together with neuronal excitability. Like other neuron …

Neurochemical atlas of the rabbit spinal cord

A Veshchitskii, P Shkorbatova… - Brain Structure and …, 2024 - Springer
Complex neurophysiological and morphologic experiments require suitable animal models
for investigation. The rabbit is one of the most successful models for studying spinal cord …

Trans-Spinal Direct Current Stimulation Targets Ca2+ Channels to Induce Persistent Motor Unit Responses

W Song, JH Martin - Frontiers in Neuroscience, 2022 - frontiersin.org
Trans-spinal direct current stimulation (tsDCS) is a neuromodulatory approach to augment
spinal cord activity to improve function after neurological disease and injury. Little is known …

Neuronal branching is increasingly asymmetric near synapses, potentially enabling plasticity while minimizing energy dissipation and conduction time

P Desai-Chowdhry, AB Brummer… - Journal of the …, 2023 - royalsocietypublishing.org
Neurons' primary function is to encode and transmit information in the brain and body. The
branching architecture of axons and dendrites must compute, respond and make decisions …

Spinal motoneurons respond aberrantly to serotonin in a rabbit model of cerebral palsy

EJ Reedich, LT Genry, PR Steele… - The Journal of …, 2023 - Wiley Online Library
Cerebral palsy (CP) is caused by a variety of factors that damage the developing central
nervous system. Impaired motor control, including muscle stiffness and spasticity, is the …

Age-related increase in the excitability of mouse layer V pyramidal neurons in the primary motor cortex is accompanied by an increased persistent inward current

JA Viteri, N Bueschke, JM Santin, WD Arnold - GeroScience, 2024 - Springer
Sarcopenia, or pathological age-related loss of muscle strength and mass, contributes to
physical function impairment in older adults. While current understanding of sarcopenia is …

M‐type potassium currents differentially affect activation of motoneuron subtypes and tune recruitment gain

SA Sharples, MJ Broadhead, JA Gray… - The Journal of …, 2023 - Wiley Online Library
The size principle is a key mechanism governing the orderly recruitment of motor units and
is believed to be dependent on passive properties of the constituent motoneurons. However …

Maturation of persistent and hyperpolarization-activated inward currents shape the recruitment of motoneuron subtypes during postnatal development

SA Sharples, GB Miles - bioRxiv, 2021 - biorxiv.org
The fine control of movement is a prerequisite for complex behaviour and is mediated by the
orderly recruitment of motor units composed of slow and fast twitch muscle fibres. The size …