The compartmentalization of the cerebellum into modules is often used to discuss its
function. What, exactly, can be considered a module, how do they operate, can they be …

Coding principles are central to understanding the organization of brain circuitry. Sparse
coding offers several advantages, but a near-consensus has developed that it only has …

Single-wavelength fluorescent reporters allow visualization of specific neurotransmitters with
high spatial and temporal resolution. We report variants of intensity-based glutamate …

The nanoscale topographical arrangement of voltage-gated calcium channels (VGCC) and
synaptic vesicles (SVs) determines synaptic strength and plasticity, but whether distinct …

Variance analysis of postsynaptic current amplitudes suggests the presence of distinct
docking sites (also called release sites) where vesicles pause before exocytosis. Docked …

The cerebellum plays a crucial role in the regulation of locomotion, but how movement is
represented at the synaptic level is not known. Here, we use in vivo patch-clamp recordings …

Fast synaptic transmission is important for rapid information processing. To explore the
maximal rate of neuronal signaling and to analyze the presynaptic mechanisms, we focused …

The parallel fiber-Purkinje cell (PF-PC) synapse represents the point of maximal signal
divergence in the cerebellar cortex with an estimated number of about 60 billion synaptic …

The cerebellar granular layer has been suggested to perform a complex spatiotemporal
reconfiguration of incoming mossy fiber signals. Central to this role is the inhibitory action …

Heterozygous and rare homozygous mutations in PRoline-Rich Transmembrane protein 2
(PRRT2) underlie a group of paroxysmal disorders including epilepsy, kinesigenic …