DNA single-strand breaks (SSBs) are among the most common lesions arising in human
cells, with tens to hundreds of thousands arising in each cell, each day. Cells have efficient …

Genome damage and transcription are intimately linked. Tens to hundreds of thousands of
DNA lesions arise in each cell each day, many of which can directly or indirectly impede …

With the development and wide usage of CRISPR technology, the presence of R-loop
structures, which consist of an RNA: DNA hybrid and a displaced single strand (ss) DNA …

BRCA1 mutations are associated with increased breast and ovarian cancer risk. BRCA1-
mutant tumors are high-grade, recurrent, and often become resistant to standard therapies …

R-loops are atypical, three-stranded nucleic acid structures that contain a stretch of RNA:
DNA hybrids and an unpaired, single stranded DNA loop. R-loops are physiological relevant …

R-loops are abundant and dynamic structures ubiquitously present in human cells both in
the nuclear and mitochondrial genomes. They form in cis in the wake of transcription …

The biological implications of R-loops are increasingly receiving attention in plant biology.
Compared with recent progresses in humans, the studies of R-loops in plants are lagging …

DNA double-strand breaks (DSBs) are lesions that arise frequently from exposure to
damaging agents as well as from ongoing physiological DNA transactions. Mis-repair of …

Simple Summary Brain tumours are a leading cause of cancer-related death in people
under the age of 40, but most remain untreatable. There is an urgent need for a greater …

The nuclear pore complex (NPC) is responsible for the exchanges between the nucleus and
the cytoplasm. NPCs are remarkable for the sophistication and the conservation of their …