Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …

Natural killer (NK) cells are effector lymphocytes of the innate immune system that control
several types of tumors and microbial infections by limiting their spread and subsequent …

Autoimmune diseases generally result from the loss of self-tolerance (ie, failure of the
immune system to distinguish self from non-self), and are characterized by autoantibody …

Activating and inhibitory receptors control natural killer (NK) cell activity. T-cell
immunoglobulin and ITIM (immunoreceptor tyrosine-based inhibition motif) domain (TIGIT) …

Natural killer (NK) cells contribute to a variety of innate immune responses to viruses, tumors
and allogeneic cells. However, our understanding of NK cell biology is severely limited by …

BACKGROUND. Despite natural killer (NK) cells being originally identified and named
because of their ability to kill tumor cells in vitro, only limited information is available on NK …

From the early days of natural killer (NK) cell research, it was clear that MHC genes
controlled the specificity of mouse NK cell-dependent responses, such as the ability to reject …

Regulatory T cells (Treg) are key players in the maintenance of peripheral tolerance. As a
result of suppressive effects on CD4+ and CD8+ effector T cells, Treg control the adaptive …

Natural killer (NK) cells have been implicated in tumour surveillance and in the early control
of several microbial infections. In autoimmune disease their involvement in these processes …

Evidence from animal models suggests that natural killer (NK) cells can be important players
in the development of type 1 diabetes, although data in humans are still sparse. We studied …