Viruses have been repurposed into tools for gene delivery by transforming them into viral
vectors. The most frequently used vectors are lentiviral vectors (LVs), derived from the …

Lymphocytes have always been among the prime targets in gene therapy, even more so
since chimeric antigen receptor (CAR) T cells have reached the clinic. However, other gene …

Transplantation of B cells engineered ex vivo to secrete broadly neutralizing antibodies
(bNAbs) has shown efficacy in disease models. However, clinical translation of this …

Effective vaccines inducing lifelong protection against many important infections such as
respiratory syncytial virus (RSV), HIV, influenza virus, and Epstein-Barr virus (EBV) are not …

ABSTRACT HIV viremia can be controlled by chronic antiretroviral therapy. As a potentially
single-shot alternative, B cells engineered by CRISPR/Cas9 to express anti-HIV broadly …

Abstract Treatment with ionizing radiation (IR) can lead to the accumulation of tumor-
infiltrating regulatory T cells (Treg cells) and subsequent resistance of tumors to …

B cells offer unique opportunities for gene therapy because of their ability to secrete large
amounts of protein in the form of antibody and persist for the life of the organism as plasma …

The expansion of genetic engineering has brought a new dimension for synthetic
immunology. Immune cells are perfect candidates because of their ability to patrol the body …

Evolutionary observations have often served as an inspiration for biological design.
Decoding of the central dogma of life at a molecular level and understanding of the cellular …

Nowadays, cancers still represent a significant health burden, accounting for around 10
million deaths per year, due to ageing populations and inefficient treatments for some …