[PDF][PDF] Lapachol: an overview

H Hussain, K Krohn, VU Ahmad, GA Miana, IR Green - Arkivoc, 2007 - arkat-usa.org
Lapachol is a naphthoquinone that was first isolated by E. Paterno from Tabebuia
avellanedae (Bignoniaceae) in 1882. A wide spectrum of therapeutic activities have been …

Lawsone in organic synthesis

AK Jordão, MD Vargas, AC Pinto, FC da Silva… - RSC …, 2015 - pubs.rsc.org
Lawsone (1) is a special naphthoquinone that is useful for many applications in various
scientific and technological fields. For over 100 years, it has been used as the starting …

Molluscicides against the snail-intermediate host of Schistosoma: a review

L Zheng, L Deng, Y Zhong, Y Wang, W Guo, X Fan - Parasitology research, 2021 - Springer
Schistosomiasis, a neglected tropical disease (NTD), is one of the most prevalent
parasitoses in the World. Certain freshwater snail species are the intermediate host in the …

Organic functionalization of ultradispersed nanodiamond: synthesis and applications

WW Zheng, YH Hsieh, YC Chiu, SJ Cai… - Journal of Materials …, 2009 - pubs.rsc.org
This work describes the chemical modification of ultradispersed nanodiamond results in the
enrichment of the surface hydroxyl groups as by FT-IR, TGA, RGA-MS and XRD …

Addition of thiols to o-quinone methide: new 2-hydroxy-3-phenylsulfanylmethyl [1, 4] naphthoquinones and their activity against the human malaria parasite …

A Sharma, IO Santos, P Gaur, VF Ferreira… - European Journal of …, 2013 - Elsevier
A series of 36 new phenylsulfanylmethyl [1, 4] naphthoquinones (7–42) were synthesized by
a three-component reaction that involves lawsone, the appropriate aldehyde and thiols with …

β-Nitrostyrene derivatives as potential antibacterial agents: A structure–property–activity relationship study

N Milhazes, R Calheiros, MPM Marques… - Bioorganic & medicinal …, 2006 - Elsevier
A multidisciplinary project was developed, combining the synthesis of a series of β-
nitrostyrene derivatives and the determination of their physicochemical parameters (redox …

Quinone-based molecular electrochemistry and their contributions to medicinal chemistry: A look at the present and future

TL Silva, SG Maria de Lourdes, FR Ferreira… - Current Opinion in …, 2020 - Elsevier
Molecular electrochemistry is closely linked to life sciences. Electron transfers play important
roles in the bioactivation of redox-active drugs, in their metabolism/catabolism, and in their …

On the search for potential anti-Trypanosoma cruzi drugs: Synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1, 2, 3-triazolic naphthoquinoidal …

EN da Silva Junior, IMM de Melo, EBT Diogo… - European journal of …, 2012 - Elsevier
Five 2-hydroxy-3-substituted-aminomethyl naphthoquinones, nine 1, 2, 3-triazolic para-
naphthoquinones, five nor-β-lapachone-based 1, 2, 3-triazoles, and several other …

Exploring the DNA binding/cleavage, cellular accumulation and topoisomerase inhibition of 2-hydroxy-3-(aminomethyl)-1, 4-naphthoquinone Mannich bases and their …

AP Neves, MXG Pereira, EJ Peterson, R Kipping… - Journal of inorganic …, 2013 - Elsevier
Several chlorido and amino Pt2+ complexes of 2-hydroxy-3-(aminomethyl)-1, 4-
naphthoquinone Mannich bases HL exhibiting moderate to high cytotoxicity against cancer …

[PDF][PDF] Preclinical and clinical studies of lapachol and beta-lapachone

ER De Almeida - Open Nat Prod J, 2009 - benthamopenarchives.com
Lapachol whose isolation and study at the end of the century by Parternó, is one of the most
brilliant chapters of Phytochemistry, especially in conjunction with the work of Max Siewert a …