Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

The assembly of functional neural circuits requires the combined action of progressive and
regressive events. Regressive events encompass a variety of inhibitory developmental …

Immune molecules, including complement proteins C1q and C3, have emerged as critical
mediators of synaptic refinement and plasticity. Complement localizes to synapses and …

The precise wiring of the nervous system is a combined outcome of progressive and
regressive events during development. Axon guidance and synapse formation intertwined …

Gene editing by CRISPR/Cas9 is commonly used to generate germline mutations or perform
in vitro screens, but applicability for in vivo screening has so far been limited. Recently, it …

Senescence is a cellular state which involves cell cycle arrest and a proinflammatory
phenotype, and it has traditionally been associated with cellular and organismal aging …

The transforming growth factor β (TGF-β) family signaling pathway is conserved and
ubiquitous in animals. In Drosophila, fewer representatives of each signaling component are …

The mushroom body (MB) is a computational center in the Drosophila brain. The intricate
neural circuits of the mushroom body enable it to store associative memories and process …

Highlights•Astrocytes induce synaptogenesis through heterogenous mechanisms.•
Astrocytes are necessary for the refinement of synapses during development.•Astrocytes are …

Highlights•Neuronal pruning is a widespread strategy crucial for refining the nervous
systems.•MB γ and ddaC neurons are two attractive models for studying neurite …