Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects

CY Ma, Y Zhai, CT Li, J Liu, X Xu… - Medicinal Research …, 2024 - Wiley Online Library
Mesenchymal stem cells (MSCs) are one of the few stem cell types used in clinical practice
as therapeutic agents for immunomodulation and ischemic tissue repair, due to their unique …

Mesenchymal stem cells in preclinical cancer cytotherapy: a systematic review

I Christodoulou, M Goulielmaki, M Devetzi… - Stem Cell Research & …, 2018 - Springer
Mesenchymal stem cells (MSC) comprise a heterogeneous population of rapidly
proliferating cells that can be isolated from adult (eg, bone marrow, adipose tissue) as well …

Expansion of human mesenchymal stem/stromal cells (hMSCs) in bioreactors using microcarriers: lessons learnt and what the future holds

PS Couto, MC Rotondi, A Bersenev, CJ Hewitt… - Biotechnology …, 2020 - Elsevier
Human mesenchymal stem/stromal cells (hMSCs) present a key therapeutic cellular
intervention for use in cell and gene therapy (CGT) applications due to their …

Strategies to improve homing of mesenchymal stem cells for greater efficacy in stem cell therapy

H Naderi‐Meshkin, AR Bahrami… - Cell biology …, 2015 - Wiley Online Library
Stem/progenitor cell‐based therapeutic approach in clinical practice has been an elusive
dream in medical sciences, and improvement of stem cell homing is one of major challenges …

Magnetic induction heating of superparamagnetic nanoparticles during rewarming augments the recovery of hUCM-MSCs cryopreserved by vitrification

J Wang, G Zhao, Z Zhang, X Xu, X He - Acta Biomaterialia, 2016 - Elsevier
Cryopreservation by vitrification has been recognized as a promising strategy for long-term
banking of living cells. However, the difficulty to generate a fast enough heating rate to …

Mesenchymal stromal cells induce regulatory T cells via epigenetic conversion of human conventional CD4 T cells in vitro

RI Azevedo, E Minskaia, A Fernandes-Platzgummer… - Stem Cells, 2020 - academic.oup.com
Regulatory T cells (Treg) play a critical role in immune tolerance. The scarcity of Treg
therapy clinical trials in humans has been largely due to the difficulty in obtaining sufficient …

Influences of xeno-free media on mesenchymal stem cell expansion for clinical application

HTH Bui, LT Nguyen, UTT Than - Tissue engineering and regenerative …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are multipotent somatic stem/progenitor cells that
can be isolated from various tissues and have attracted increasing attention from the …

Scalable microcarrier-based manufacturing of mesenchymal stem/stromal cells

AM de Soure, A Fernandes-Platzgummer… - Journal of …, 2016 - Elsevier
Due to their unique features, mesenchymal stem/stromal cells (MSC) have been exploited in
clinical settings as therapeutic candidates for the treatment of a variety of diseases …

[HTML][HTML] Optimization of pre-transplantation conditions to enhance the efficacy of mesenchymal stem cells

N Haque, NHA Kasim, MT Rahman - International journal of …, 2015 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) are considered a potential tool for cell based regenerative
therapy due to their immunomodulatory property, differentiation potentials, trophic activity as …

Stirred tank bioreactor culture combined with serum‐/xenogeneic‐free culture medium enables an efficient expansion of umbilical cord‐derived mesenchymal stem …

A Mizukami, A Fernandes‐Platzgummer… - Biotechnology …, 2016 - Wiley Online Library
Mesenchymal stem/stromal cells (MSC) are being widely explored as promising candidates
for cell‐based therapies. Among the different human MSC origins exploited, umbilical cord …