Ion Mobility Spectrometry (IMS) is a widely used and 'well-known'technique of ion separation
in the gaseous phase based on the differences in ion mobilities under an electric field. All …

The field of ion mobility-mass spectrometry (IM-MS) has grown with significant momentum in
recent years in both fundamental advances and pioneering applications. A search of the …

Improvements in the performance and availability of commercial instrumentation have made
ion mobility-mass spectrometry (IM-MS) an increasingly popular approach for the structural …

Highlights•Collision induced unfolding (CIU) uses gas phase activation to probe
biomolecules.•CIU can detect subtle changes in protein structure, stability or …

This review article compares and contrasts various types of ion mobility–mass spectrometers
available today and describes their advantages for application to a wide range of analytes …

Ion mobility coupled with mass spectrometry has evolved into a powerful analytical
technique for investigating the gas-phase structures of bio-molecules. Here we present the …

Mass spectrometry (MS)–based high-throughput proteomics is the core technique for large-
scale protein characterization. Due to the extreme complexity of proteomes, sophisticated …

Traditionally, mass spectrometry has been a powerful analytical method enabling the
structural analysis of small molecules, and later on peptides and proteins. With the advent of …

The technique of ion mobility mass spectrometry (IM-MS) has become of increasing interest
for rapid analysis of the conformations adopted by biological macromolecules. It is currently …

Although nonnative protein conformations, including intermediates along the folding
pathway and kinetically trapped misfolded species that disfavor the native state, are rarely …