Neurofilament proteins have been validated as specific body fluid biomarkers of neuro-
axonal injury. The advent of highly sensitive analytical platforms that enable reliable …

Huntington's disease (HD) is characterized by clinical motor impairment (eg, involuntary
movements, poor coordination, parkinsonism), cognitive deficits, and psychiatric symptoms …

Summary Background The recently proposed Huntington's Disease Integrated Staging
System (HD-ISS) categorises individuals with the Huntintin genetic mutation into disease …

Huntington's disease is a progressive neurodegenerative disease caused by mutation of the
huntingtin (HTT) gene. The identification of mutation carriers before symptom onset provides …

Abstract Background In Huntington's disease clinical trials, recruitment and stratification
approaches primarily rely on genetic load, cognitive and motor assessment scores. They …

Summary Background Neurofilament light (NfL) has previously been highlighted as a
potential biomarker for Huntington's Disease (HD) using cross-sectional analyses. Our study …

Introduction Strong evidence suggests a significant role for iron accumulation in the brain in
addition to the well-documented neurodegenerative aspects of Huntington's disease (HD) …

Proton magnetic resonance spectroscopy (1 H-MRS) allows measuring specific brain
metabolic alterations in Huntington's disease (HD), and these metabolite profiles may serve …

Background Growing evidence supports the value of neurofilament light (NfL) as a
prognostic biomarker in premanifest Huntington's disease (HD). To date, however, there has …

The characterization of the Huntingtin gene in 1993, 10 years after it was the first disease-
associated gene to be mapped to a chromosome in humans, brought with it much …