This theoretical article revives a classical bridging construct, canalization, to describe a new
model of a general factor of psychopathology. To achieve this, we have distinguished …

No contemporary unifying framework has been provided for the study of non-ordinary states
of consciousness (NSCs) despite increased interest in hypnosis, meditation, and …

Importance Psilocybin shows promise as a treatment for major depressive disorder (MDD).
Objective To evaluate the magnitude, timing, and durability of antidepressant effects and …

A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time
perception and ego dissolution, produces rapid and persistent therapeutic effects in human …

Design Open-label Randomized Randomized, double-blind, placebo-controlled
Randomized, double-blind, placebo-controlled Randomized, double-blind, placebo …

Psychedelics, also known as classical hallucinogens, have been investigated for decades
due to their potential therapeutic effects in the treatment of neuropsychiatric and substance …

Research in the last decade has expressed considerable optimism about the clinical
potential of psychedelics for the treatment of mental disorders. This optimism is reflected in …

Therapeutic claims about many psychedelic drugs have not been evaluated in any studies
of even modest rigor. The science of psychedelic drugs is strengthening however, making it …

Background Psychedelic-assisted therapy [eg, with lysergic acid diethylamide (LSD)] has
shown promising results as treatment for substance use disorders (SUDs). Previous …

The aim of this review was to determine the effect of psilocybin on depressive symptoms in
patients diagnosed with life-threatening illnesses or major depressive disorder. Systematic …