The NADPH Link between the Renin Angiotensin System and the Antioxidant Mechanisms in Dopaminergic Neurons

R Franco, J Serrano-Marín, G Navarro… - Antioxidants, 2023 - mdpi.com
The renin angiotensin system (RAS) has several components including signaling peptides,
enzymes, and membrane receptors. The effort in characterizing this system in the periphery …

The unbroken Krebs cycle. Hormonal‐like regulation and mitochondrial signaling to control mitophagy and prevent cell death

R Franco, J Serrano‐Marín - BioEssays, 2023 - Wiley Online Library
The tricarboxylic acid (TCA) or Krebs cycle, which takes place in prokaryotic cells and in the
mitochondria of eukaryotic cells, is central to life on Earth and participates in key events such …

Cognitive, behavioral and metabolic effects of oral galactose treatment in the transgenic Tg2576 mice

AB Perhoc, JO Barilar, A Knezovic, V Farkas… - …, 2019 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disorder associated with
insulin resistance and glucose hypometabolism in the brain. Oral administration of …

Can chronic therapeutic drug use by the elderly affect Alzheimers disease risk and rate of progression?

R Franco, J Serrano-Marín - Exploration of Neuroprotective …, 2023 - explorationpub.com
There is no approved drug capable of halting the progression of the most prevalent
neurodegenerative disorders, namely Alzheimer's disease (AD) and Parkinson's disease …

Imprinted genes and multiple sclerosis: What do we know?

N Baulina, I Kiselev, O Favorova - International journal of molecular …, 2021 - mdpi.com
Multiple sclerosis (MS) is a chronic autoimmune neurodegenerative disease of the central
nervous system that arises from interplay between non-genetic and genetic risk factors. The …

Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APPswe Alzheimer's Disease Mouse Model

M Zamarbide, E Martinez-Pinilla, F Gil-Bea… - International journal of …, 2022 - mdpi.com
The free fatty acid FFA3 receptor (FFA3R) belongs to the superfamily of G-protein-coupled
receptors (GPCRs). In the intestine and adipose tissue, it is involved in the regulation of …

Lessons on differential neuronal-death-vulnerability from familial cases of Parkinson's and Alzheimer's diseases

R Franco, G Navarro, E Martínez-Pinilla - International Journal of …, 2019 - mdpi.com
The main risk of Alzheimer's disease (AD) and Parkinson's disease (PD), the two most
common neurodegenerative pathologies, is aging. In contrast to sporadic cases, whose …

Robustness of the krebs cycle under physiological conditions and in cancer: new clues for evaluating metabolism-modifying drug therapies

R Franco, J Serrano-Marín - Biomedicines, 2022 - mdpi.com
The Krebs cycle in cells that contain mitochondria is necessary for both energy production
and anabolic processes. In given cell/condition, the Krebs cycle is dynamic but remains at a …

Noncanonical regulation of imprinted gene Igf2 by amyloid-beta 1–42 in Alzheimer's disease

E Fertan, WH Gendron, AA Wong, GM Hanson… - Scientific Reports, 2023 - nature.com
Reduced insulin-like growth factor 2 (IGF2) levels in Alzheimer's disease (AD) may be the
mechanism relating age-related metabolic disorders to dementia. Since Igf2 is an imprinted …

[HTML][HTML] Plant-derived compounds, vitagens, vitagenes and mitochondrial function

R Franco, G Navarro, E Martínez-Pinilla - PharmaNutrition, 2022 - Elsevier
There is great interest in identifying natural products that can be approved as nutraceuticals.
A good option is to induce transcription of vitagenes, which would lead to increased …