Inflammation and tumor progression: signaling pathways and targeted intervention

H Zhao, L Wu, G Yan, Y Chen, M Zhou… - Signal transduction and …, 2021 - nature.com
Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Targeting macrophages in cancer immunotherapy

Z Duan, Y Luo - Signal transduction and targeted therapy, 2021 - nature.com
Immunotherapy is regarded as the most promising treatment for cancers. Various cancer
immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies …

Redefining tumor-associated macrophage subpopulations and functions in the tumor microenvironment

K Wu, K Lin, X Li, X Yuan, P Xu, P Ni, D Xu - Frontiers in immunology, 2020 - frontiersin.org
The immunosuppressive status of the tumor microenvironment (TME) remains poorly
defined due to a lack of understanding regarding the function of tumor-associated …

Tumor-associated macrophages (TAMs) in colorectal cancer (CRC): from mechanism to therapy and prognosis

H Wang, T Tian, J Zhang - International journal of molecular sciences, 2021 - mdpi.com
Colorectal cancer (CRC) is a malignant tumor in the digestive system whose incidence and
mortality is high-ranking among tumors worldwide. The initiation and progression of CRC is …

The dual role of tumor necrosis factor-alpha (TNF-α) in breast cancer: molecular insights and therapeutic approaches

D Cruceriu, O Baldasici, O Balacescu… - Cellular Oncology, 2020 - Springer
Background Breast cancer is the most prevalent cancer among women worldwide and the
fifth cause of death among all cancer patients. Breast cancer development is driven by …

Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities

C Lu, D Rong, B Zhang, W Zheng, X Wang, Z Chen… - Molecular cancer, 2019 - Springer
Incidence of hepatocellular carcinoma (HCC) is on the rise due to the prevalence of chronic
hepatitis and cirrhosis. Although there are surgical and chemotherapy treatment avenues …

Adaptive mechanisms of tumor therapy resistance driven by tumor microenvironment

P Wu, W Gao, M Su, EC Nice, W Zhang… - Frontiers in cell and …, 2021 - frontiersin.org
Cancer is a disease which frequently has a poor prognosis. Although multiple therapeutic
strategies have been developed for various cancers, including chemotherapy, radiotherapy …

Tumor-associated macrophages as multifaceted regulators of breast tumor growth

MT Munir, MK Kay, MH Kang, MM Rahman… - International journal of …, 2021 - mdpi.com
Breast cancer is the most commonly occurring cancer in women of Western countries and is
the leading cause of cancer-related mortality. The breast tumor microenvironment contains …

Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer

X Liu, S Zhao, K Wang, L Zhou, M Jiang, Y Gao… - Nature …, 2023 - nature.com
Esophageal squamous precancerous lesions (ESPL) are the precursors of esophageal
squamous cell carcinoma (ESCC) including low-grade and high-grade intraepithelial …

Tumor-associated macrophages: a potential target for cancer therapy

Y Tan, M Wang, Y Zhang, S Ge, F Zhong, G Xia… - Frontiers in …, 2021 - frontiersin.org
Macrophages, an important class of innate immune cells that maintain body homeostasis
and ward off foreign pathogens, exhibit a high degree of plasticity and play a supportive role …