Influenza and antiviral resistance: an overview

T Lampejo - European Journal of Clinical Microbiology & Infectious …, 2020 - Springer
Influenza affects approximately 1 billion individuals each year resulting in between 290,000
and 650,000 deaths. Young children and immunocompromised individuals are at a …

Advances in droplet digital polymerase chain reaction on microfluidic chips

D Xu, W Zhang, H Li, N Li, JM Lin - Lab on a Chip, 2023 - pubs.rsc.org
The PCR technique has been known to the general public since the pandemic outbreak of
COVID-19. This technique has progressed through three stages: from simple PCR to real …

Droplet digital PCR as an emerging tool in detecting pathogens nucleic acids in infectious diseases

B Chen, Y Jiang, X Cao, C Liu, N Zhang, D Shi - Clinica chimica acta, 2021 - Elsevier
The microbial infectious diseases (infectious diseases) represent the leading global public
health problem, and the effective treatment depends on rapid and accurate detection of …

Digital PCR—an emerging technology with broad applications in microbiology

SJ Salipante, KR Jerome - Clinical chemistry, 2020 - academic.oup.com
BACKGROUND The PCR and its variant, quantitative PCR (qPCR), have revolutionized the
practice of clinical microbiology. Continued advancements in PCR have led to a new …

Neuraminidase inhibitor resistance in influenza: a clinical perspective

N Lee, AC Hurt - Current opinion in infectious diseases, 2018 - journals.lww.com
These findings highlight the importance of continuous surveillance, and assessment of viral
fitness and transmissibility of resistant virus strains. Detection can be challenging, especially …

Quality control implementation for universal characterization of DNA and RNA viruses in clinical respiratory samples using single metagenomic next-generation …

A Bal, M Pichon, C Picard, JS Casalegno… - BMC infectious …, 2018 - Springer
Background In recent years, metagenomic Next-Generation Sequencing (mNGS) has
increasingly been used for an accurate assumption-free virological diagnosis. However, the …

Recent advances in droplet microfluidics for microbiology

Z He, H Wu, X Yan, W Liu - Chinese Chemical Letters, 2022 - Elsevier
Advances in microbiology rely on innovations in technology. Droplet microfluidics, as a
versatile and powerful technique that allows high-throughput generation and manipulation …

Seasonal genetic drift of human influenza A virus quasispecies revealed by deep sequencing

C Barbezange, L Jones, H Blanc, O Isakov… - Frontiers in …, 2018 - frontiersin.org
After a pandemic wave in 2009 following their introduction in the human population, the
H1N1pdm09 viruses replaced the previously circulating, pre-pandemic H1N1 virus and …

Development of digital droplet PCR targeting the influenza H3N2 oseltamivir-resistant E119V mutation and its performance through the use of reverse genetics …

LAE Van Poelvoorde, FE Dufrasne… - Current Issues in …, 2023 - mdpi.com
The monitoring of antiviral-resistant influenza virus strains is important for public health
given the availability and use of neuraminidase inhibitors and other antivirals to treat …

Design of new chemical entities targeting both native and H275Y mutant influenza a virus by deep reinforcement learning

M Matevosyan, V Harutyunyan, N Abelyan… - Journal of …, 2023 - Taylor & Francis
Influenza virus remains a major public health challenge due to its high morbidity and
mortality and seasonal surge. Although antiviral drugs against the influenza virus are widely …