Understanding the structural heterogeneity inherent in the process of amyloid fibril formation
is an important goal of protein aggregation studies. Structural heterogeneity in amyloid fibrils …

Interest in protein folding intermediates lies in their significance to protein folding pathways.
The molten globule (MG) state is one such intermediate lying on the kinetic (and sometimes …

MATERIALS AND METHODS Protein Purification. The plasmid encoding the gene for
barstar (pMT316) was a generous gift from Dr. RW Hartley (1988) and was expressed in …

The conformational transitions starting with the native protein, passing the molten globule
state and finally approaching the unfolded state of proteins was investigated for bovine …

Due to its unique optical properties, nanostructured silicon is a promising material for
optoelectronic applications, solar energy conversion and chemical sensors. This paper …

The absorption and luminescence originating from protein charge transfer spectra
(ProCharTS) depend on the proximity between multiple charged groups in a protein. This …

The early intermediates in the protein aggregation pathway, the elusive soluble aggregates,
play a pivotal role in growth and maturation of ordered aggregates such as amyloid fibrils …

Maximum entropy method (MEM) was used for resolving multiple decay components in
synthetic and experimental time-resolved fluorescence decay. The distribution of lifetimes is …

Abstract l-Lysine displays new absorption and fluorescence features at high concentrations
(∼ 0.5 M) in aqueous medium. A new absorption peak was detected around∼ 270 nm (ε …

Understanding the heterogeneity of the soluble oligomers and protofibrillar structures that
form initially during the process of amyloid fibril formation is a critical aspect of elucidating …