The threat of programmed DNA damage to neuronal genome integrity and plasticity
KW Caldecott, ME Ward, A Nussenzweig - Nature Genetics, 2022 - nature.com
The neuronal genome is particularly sensitive to loss or attenuation of DNA repair, and many
neurological diseases ensue when DNA repair is impaired. It is well-established that the …
neurological diseases ensue when DNA repair is impaired. It is well-established that the …
Biochemistry and use of soybean isoflavones in functional food development
C Hu, WT Wong, R Wu, WF Lai - Critical Reviews in Food Science …, 2020 - Taylor & Francis
Soybeans and their food products exist in the market in various forms, ranging from crude
oils and bean meals to nutritious products (eg soy milk powers). With the availability of …
oils and bean meals to nutritious products (eg soy milk powers). With the availability of …
Neuronal enhancers are hotspots for DNA single-strand break repair
Defects in DNA repair frequently lead to neurodevelopmental and neurodegenerative
diseases, underscoring the particular importance of DNA repair in long-lived post-mitotic …
diseases, underscoring the particular importance of DNA repair in long-lived post-mitotic …
Topoisomerase II-induced chromosome breakage and translocation is determined by chromosome architecture and transcriptional activity
Topoisomerase II (TOP2) relieves torsional stress by forming transient cleavage complex
intermediates (TOP2ccs) that contain TOP2-linked DNA breaks (DSBs). While TOP2ccs are …
intermediates (TOP2ccs) that contain TOP2-linked DNA breaks (DSBs). While TOP2ccs are …
Spatial chromosome folding and active transcription drive DNA fragility and formation of oncogenic MLL translocations
HJ Gothe, BAM Bouwman, EG Gusmao, R Piccinno… - Molecular cell, 2019 - cell.com
How spatial chromosome organization influences genome integrity is still poorly understood.
Here, we show that DNA double-strand breaks (DSBs) mediated by topoisomerase 2 (TOP2) …
Here, we show that DNA double-strand breaks (DSBs) mediated by topoisomerase 2 (TOP2) …
RAD54L2 counters TOP2-DNA adducts to promote genome stability
G D'Alessandro, DA Morales-Juarez, SL Richards… - Science …, 2023 - science.org
The catalytic cycle of topoisomerase 2 (TOP2) enzymes proceeds via a transient DNA
double-strand break (DSB) intermediate termed the TOP2 cleavage complex (TOP2cc), in …
double-strand break (DSB) intermediate termed the TOP2 cleavage complex (TOP2cc), in …
Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways
Topoisomerases play a pivotal role in ensuring DNA metabolisms during replication,
transcription and chromosomal segregation. To manage DNA topology, topoisomerases …
transcription and chromosomal segregation. To manage DNA topology, topoisomerases …
Tyrosyl–DNA phosphodiesterases: Rescuing the genome from the risks of relaxation
AS Kawale, LF Povirk - Nucleic acids research, 2018 - academic.oup.com
Abstract Tyrosyl–DNA Phosphodiesterases 1 (TDP1) and 2 (TDP2) are eukaryotic enzymes
that clean-up after aberrant topoisomerase activity. While TDP1 hydrolyzes phosphotyrosyl …
that clean-up after aberrant topoisomerase activity. While TDP1 hydrolyzes phosphotyrosyl …
Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement
ZH Gray, D Chakraborty, RR Duttweiler, GD Alekbaeva… - Cell, 2023 - cell.com
Summary MLL/KMT2A amplifications and translocations are prevalent in infant, adult, and
therapy-induced leukemia. However, the molecular contributor (s) to these alterations are …
therapy-induced leukemia. However, the molecular contributor (s) to these alterations are …
Type II DNA topoisomerases cause spontaneous double-strand breaks in genomic DNA
Type II DNA topoisomerase enzymes (TOP2) catalyze topological changes by strand
passage reactions. They involve passing one intact double stranded DNA duplex through a …
passage reactions. They involve passing one intact double stranded DNA duplex through a …