Sphingolipids, including the two central bioactive lipids ceramide and sphingosine-1-
phosphate (S1P), have opposing roles in regulating cancer cell death and survival …

Sphingolipids are a specialized group of lipids essential to the composition of the plasma
membrane of many cell types; however, they are primarily localized within the nervous …

Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Ceramide accumulation is a hallmark in the manifestation of numerous obesity-related
diseases, such as type 2 diabetes mellitus and atherosclerosis. Until the early 2000s …

Mitochondrial function is challenged by toxic by-products of metabolism as well as by
pathogen attack,. Caenorhabditis elegans normally responds to mitochondrial dysfunction …

Different studies corroborate a role for ceramide synthases and their downstream products,
ceramides, in modulation of apoptosis and autophagy in the context of cancer. These …

The unfolded protein response (UPR) is induced by proteotoxic stress of the endoplasmic
reticulum (ER). Here we report that ATF6, a major mammalian UPR sensor, is also activated …

Cellular stress elicited by the toxic metal Cd 2+ does not coerce the cell into committing to
die from the onset. Rather, detoxification and adaptive processes are triggered concurrently …

Mechanisms that alter protein phosphatase 2A (PP2A)‐dependent lung tumour suppression
via the I2PP2A/SET oncoprotein are unknown. We show here that the tumour suppressor …

Bile acids are ligands for the nuclear hormone receptor farnesoid X receptor (FXR) and the
G protein–coupled receptor TGR5. We have shown that FXR and TGR5 have renoprotective …