Angiotensin II (AngII), as an octapeptide hormone normally ionized at physiological pH,
cannot cross cell membranes and thus, relies on, two (mainly) G protein-coupled receptor …

Acute kidney injury (AKI) is an underestimated, yet important risk factor for development of
chronic kidney disease (CKD). Even after initial total recovery of renal function, some …

G protein-coupled receptor signaling mechanisms are implicated in many aspects of
cardiovascular control, and dysfunction of such signaling mechanisms is commonly …

The incidence and severity of acute kidney injury (AKI) is increased yearly in diabetic
patients. Although the mechanisms for this remain unclear, the prevention of AKI in diabetic …

Genetic induction of hypoxia signaling by deletion of the von Hippel-Lindau (Vhl) protein in
mesenchymal PDGFR-β+ cells leads to abundant HIF-2 dependent erythropoietin (EPO) …

Background Chronic kidney disease (CKD) patients have deficient levels of glutathione
peroxidase-3 (GPx3). We hypothesized that GPx3 deficiency may lead to cardiovascular …

Vascular progenitor cells show promise for the treatment of microvasculature endothelial
injury. We investigated the function of renal artery progenitor cells derived from radical …

Background Previous reports have shown that acute kidney injury (AKI) is common after
hematopoietic stem cell transplantation (HSCT), which is a crucial treatment for patients with …

Stratifin (SFN) is a member of the 14-3-3 family of highly conserved soluble acidic proteins,
which regulates a variety of cellular activities such as cell cycle, cell growth and …

One of the major obstacles to prevent AKI-CKD transition is the lack of effective methods to
follow and predict the ongoing kidney injury after an AKI episode. In the present study, we …