Animal models for COVID-19: advances, gaps and perspectives
C Fan, Y Wu, X Rui, Y Yang, C Ling, S Liu… - Signal transduction and …, 2022 - nature.com
Abstract COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …
Tissue factor in COVID-19-associated coagulopathy
Evidence of micro-and macro-thrombi in the arteries and veins of critically ill COVID-19
patients and in autopsies highlight the occurrence of COVID-19-associated coagulopathy …
patients and in autopsies highlight the occurrence of COVID-19-associated coagulopathy …
Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency
The use of modified nucleotides to suppress the interferon response and maintain
translation of self-amplifying RNA (saRNA), which has been achieved for mRNA, has not yet …
translation of self-amplifying RNA (saRNA), which has been achieved for mRNA, has not yet …
Macrophages and γδ T cells interplay during SARS-CoV-2 variants infection
PA Atmeh, L Gay, A Levasseur, B La Scola… - Frontiers in …, 2022 - frontiersin.org
Introduction The emergence of several SARS-CoV-2 variants during the COVID pandemic
has revealed the impact of variant diversity on viral infectivity and host immune responses …
has revealed the impact of variant diversity on viral infectivity and host immune responses …
A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: protection of African green …
S Nambulli, N Escriou, LJ Rennick, MJ Demers… - Journal of …, 2024 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at the end of
2019 and is responsible for the largest human pandemic in 100 years. Thirty-four vaccines …
2019 and is responsible for the largest human pandemic in 100 years. Thirty-four vaccines …
Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses
JA Hartmann, MR Cardoso, MCR Talarico, DJ Kenney… - Cell, 2024 - cell.com
SARS-CoV-2 and other sarbecoviruses continue to threaten humanity, highlighting the need
to characterize common mechanisms of viral immune evasion for pandemic preparedness …
to characterize common mechanisms of viral immune evasion for pandemic preparedness …
T Cell Development and Responses in Human Immune System Mice
M Khosravi-Maharlooei, HW Li… - Annual Review of …, 2024 - annualreviews.org
Human Immune System (HIS) mice constructed with mature human immune cells or with
human hematopoietic stem cells and thymic tissue have provided an important tool for …
human hematopoietic stem cells and thymic tissue have provided an important tool for …
Akaluc bioluminescence offers superior sensitivity to track in vivo dynamics of SARS-CoV-2 infection
Monitoring in vivo viral dynamics can improve our understanding of pathogenicity and tissue
tropism. Because the gene size of RNA viruses is typically small, NanoLuc is the primary …
tropism. Because the gene size of RNA viruses is typically small, NanoLuc is the primary …
Complete substitution with modified nucleotides suppresses the early interferon response and increases the potency of self-amplifying RNA
Self-amplifying RNA (saRNA) will revolutionize vaccines and in situ therapeutics by
enabling protein expression for longer duration at lower doses. However, a major barrier to …
enabling protein expression for longer duration at lower doses. However, a major barrier to …
Heat Inactivation of Nipah Virus for Downstream Single-Cell RNA Sequencing Does Not Interfere with Sample Quality
Single-cell RNA sequencing (scRNA-seq) technologies are instrumental to improving our
understanding of virus–host interactions in cell culture infection studies and complex …
understanding of virus–host interactions in cell culture infection studies and complex …