Disease–gene association through genome-wide association study (GWAS) is an arduous
task for researchers. Investigating single nucleotide polymorphisms that correlate with …

Motivation Genome-wide association studies (GWAS) have enabled large-scale analysis of
the role of genetic variants in human disease. Despite impressive methodological advances …

Primary biliary cholangitis (PBC) is a chronic, cholestatic, immune-mediated, and
progressive liver disorder. Treatment to preventing the disease from advancing into later and …

Traditional techniques for identifying disease genes and disease modules involve high-cost
clinical experiments and unpredictable time consumption for analysis. Network-based …

Background: Phenotype similarity calculation should be used to help improve drug
repurposing. In this study, based on the MeSH terms describing the phenotypes deposited in …

Traditional techniques for identifying disease genes and disease modules involve high-cost
clinical experiments and unpredictable time consumption for analysis. Network-based …

Although lots of algorithms for disease gene prediction have been proposed, the weights of
edges are rarely taken into account. In this paper, the strengths of topology associations …

In recent years, with the development of high-throughput technologies and the increase of
omics data, molecular diagnostics and the analysis of patients' exact causative genes …

The analysis of disease-causing conditions based on genes and their protein products plays
a crucial role in the diagnosis and treatment of several serious diseases such as cancer and …

I would like to acknowledge my two thesis advisors for making my trip through graduate
school possible. Todd McDevitt and Melissa Kemp provided me with the freedom to pursue …