Proteases have an important role in many signalling pathways, and represent potential drug
targets for diseases ranging from cardiovascular disorders to cancer, as well as for …

Accumulating evidence indicates that p38 mitogen-activated protein kinase (MAPK) could
play more than one role in Alzheimer's disease (AD) pathophysiology and that patients …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

Although allostery draws increasing attention, not much is known about allosteric
mechanisms. Here we argue that in all proteins, allosteric signals transmit through multiple …

The discovery of allosteric modulators of G protein-coupled receptors (GPCRs) provides a
promising new strategy with potential for developing novel treatments for a variety of central …

Protein kinases have become the second most exploited group of drug targets after G-
protein-coupled receptors (GPCRs), accounting for 30% of drug discovery projects at many …

(PAMs), which potentiate GABAA receptor response, and negative allosteric modulators
(NAMs), which decrease channel activity and modulate the ability of these GABAergic …

Protein kinases play crucial roles in the regulation of multiple cell signaling pathways and
cellular functions. Deregulation of protein kinase function has been implicated in …

Introduction: Because of their important roles in disease and excellent 'druggability', kinases
have become the second largest drug target family. The great success of the BCR-ABL …

The catalytic domain of kinases shows a high degree of sequence homology, especially for
kinases that belong to the same family. They share a common ATP binding site with a …