Inflammatory responses after ischemic stroke

JH DeLong, SN Ohashi, KC O'Connor… - Seminars in …, 2022 - Springer
Ischemic stroke generates an immune response that contributes to neuronal loss as well as
tissue repair. This is a complex process involving a range of cell types and effector …

Targeting the immune system for ischemic stroke

SR Zhang, TG Phan, CG Sobey - Trends in pharmacological sciences, 2021 - cell.com
Stroke is responsible for almost 6 million deaths and more than 10% of all mortalities each
year, and two-thirds of stroke survivors remain disabled. With treatments for ischemic stroke …

Neurogenesis after stroke: a therapeutic perspective

AA Rahman, N Amruta, E Pinteaux, GJ Bix - Translational stroke research, 2021 - Springer
Stroke is a major cause of death and disability worldwide. Yet therapeutic strategies
available to treat stroke are very limited. There is an urgent need to develop novel …

[HTML][HTML] MSC based gene delivery methods and strategies improve the therapeutic efficacy of neurological diseases

H Zhou, Y He, W Xiong, S Jing, X Duan, Z Huang… - Bioactive materials, 2023 - Elsevier
Mesenchymal stem cells (MSCs) are promising seed cells for neural regeneration therapy
owing to their plasticity and accessibility. They possess several inherent characteristics …

Repair mechanisms of the neurovascular unit after ischemic stroke with a focus on VEGF

S Moon, MS Chang, SH Koh, YK Choi - International Journal of Molecular …, 2021 - mdpi.com
The functional neural circuits are partially repaired after an ischemic stroke in the central
nervous system (CNS). In the CNS, neurovascular units, including neurons, endothelial …

Progress in mesenchymal stem cell therapy for ischemic stroke

Y Guo, Y Peng, H Zeng, G Chen - Stem cells international, 2021 - Wiley Online Library
Ischemic stroke (IS) is a serious cerebrovascular disease with high morbidity and disability
worldwide. Despite the great efforts that have been made, the prognosis of patients with IS …

Recent advances in cell-based therapies for ischemic stroke

S Suda, C Nito, S Yokobori, Y Sakamoto… - International Journal of …, 2020 - mdpi.com
Stroke is the most prevalent cardiovascular disease worldwide, and is still one of the leading
causes of death and disability. Stem cell-based therapy is actively being investigated as a …

Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke

L Zhou, H Zhu, X Bai, J Huang, Y Chen, J Wen… - Stem cell research & …, 2022 - Springer
Ischemic stroke is one of the major causes of death and disability in the world. Currently,
most patients cannot choose intravenous thrombolysis or intravascular mechanical …

Paracrine effects of mesenchymal stem cells in ischemic stroke: Opportunities and challenges

A Asgari Taei, P Khodabakhsh, S Nasoohi… - Molecular …, 2022 - Springer
It is well acknowledged that neuroprotective effects of transplanted mesenchymal stem cells
(MSCs) in ischemic stroke are attributed to their paracrine-mediated actions or bystander …

Oxidative stress, inflammation, and autophagy: potential targets of mesenchymal stem cells-based therapies in ischemic stroke

J He, J Liu, Y Huang, X Tang, H Xiao… - Frontiers in Neuroscience, 2021 - frontiersin.org
Ischemic stroke is a leading cause of death worldwide; currently available treatment
approaches for ischemic stroke are to restore blood flow, which reduce disability but are time …