Colorectal cancer (CRC), a leading cause of cancer-related death worldwide, evolves as a
result of the stepwise accumulation of a series of genetic and epigenetic alterations in the …

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Despite
significant progress that has been made in therapies against CRC over the past decades …

The development of novel therapeutic approaches is necessary to manage gastrointestinal
cancers (GICs). Considering the effective molecular mechanisms involved in tumor growth …

Genetic variations along with epigenetic modifications of DNA are involved in colorectal
cancer (CRC) development and progression. CRC is the fourth leading cause of cancer …

Colorectal tumors have been classified based on histologic factors, genetic factors, and
consensus molecular subtypes, all of which affect the tumor microenvironment. Elements of …

Breast cancer is one of the most common cancers and the second leading cause of cancer
death in the United States. Estrogen receptor (ER)-positive cancer is the most frequent …

Vitamin D regulates a plethora of physiological processes in the human body and has been
proposed to exert several anticancer effects. Epigenetics plays an important role in …

Abstract SETDB1, a histone H3K9 methyltransferase, has been reported to be upregulated
in a variety of tumors and promotes cancer development. However, the exact pathogenesis …

Abstract Background and Aim: DOT1L regulates various genes involved in cancer onset and
progression by catalyzing H3K79 methylation, but how DOT1L activity itself is regulated is …

Background The incidence of colorectal cancer (CRC) in younger patients is rising, mostly
due to tumors in the descending colon and rectum. Therefore, we aimed to explore the …