primate research suggests that affiliation is a highly complex construct. studies of primate
affiliation demonstrate the need to distinguish between various affiliative behaviors, consider …

Over the last several years, compelling evidence has accumulated indicating that central
hyperactive states resulting from neuronal plastic changes within the spinal cord play a …

Peroxynitrite (PN; ONOO−) and its reactive oxygen precursor superoxide (SO; O2•−) are
critically important in the development of pain of several etiologies including pain associated …

Tolerance to the analgesic effects of an opioid occurs after its chronic administration, a
pharmacological phenomenon that has been associated with the development of abnormal …

Compelling evidence has accumulated over the last several years from our laboratory, as
well as others, indicating that central hyperactive states resulting from neuronal plastic …

Tolerance to the analgesic effect of an opioid is a pharmacological phenomenon that occurs
after its prolonged administration. Activation of the NMDA receptor (NMDAR) has been …

Evidence from the last several decades indicates that the excitatory amino acid glutamate
plays a significant role in nociceptive processing. Glutamate and glutamate receptors are …

The nonopioid actions of spinal dynorphin may promote aspects of abnormal pain after
nerve injury. Mechanistic similarities have been suggested between opioid tolerance and …

Zusammenfassung Die Physiologie der Schmerzwahrnehmung beruht auf einer komplexen
Interaktion peripherer, spinaler und supraspinaler Strukturen des Zentralnervensystems …

Over the last several years, significant progress has been made in our understanding of
interactions between the N-methyl-d-aspartate (NMDA) and opioid receptors. Such …