Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …
dependent dementia. There is currently no effective treatment for AD, which may be …
Tau post-translational modifications: dynamic transformers of tau function, degradation, and aggregation
C Alquezar, S Arya, AW Kao - Frontiers in neurology, 2021 - frontiersin.org
Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …
protein function and contributing to neurodegeneration. The explosion of information on …
[HTML][HTML] X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women
Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …
Posttranslational modifications mediate the structural diversity of tauopathy strains
Tau aggregation into insoluble filaments is the defining pathological hallmark of tauopathies.
However, it is not known what controls the formation and templated seeding of strain-specific …
However, it is not known what controls the formation and templated seeding of strain-specific …
Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease
Recent demonstrations that the secretion, uptake, and interneuronal transfer of tau can be
modulated by disease-associated tau modifications suggest that secretion may be an …
modulated by disease-associated tau modifications suggest that secretion may be an …
Tau in Alzheimer's disease: mechanisms and therapeutic strategies
Y Gao, L Tan, JT Yu, L Tan - Current Alzheimer Research, 2018 - ingentaconnect.com
Objective: Alzheimer's disease (AD), the most important progressive neurodegenerative
disorder, is characterized by cognitive and behavioral disabilities. Nowadays, tau, as a …
disorder, is characterized by cognitive and behavioral disabilities. Nowadays, tau, as a …
Dysregulation of ubiquitin-proteasome system in neurodegenerative diseases
The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways,
where abnormal UPS function has been observed in cancer and neurological diseases …
where abnormal UPS function has been observed in cancer and neurological diseases …
[HTML][HTML] Acetylation of tau inhibits its degradation and contributes to tauopathy
SW Min, SH Cho, Y Zhou, S Schroeder, V Haroutunian… - Neuron, 2010 - cell.com
Neurodegenerative tauopathies characterized by hyperphosphorylated tau include
frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) and …
frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) and …
[HTML][HTML] Identification of oligomers at early stages of tau aggregation in Alzheimer's disease
CA Lasagna-Reeves, DL Castillo-Carranza… - The FASEB …, 2012 - ncbi.nlm.nih.gov
Neurofibrillary tangles (NFTs) are a pathological hallmark of Alzheimer's disease (AD);
however, the relationship between NFTs and disease progression remains controversial …
however, the relationship between NFTs and disease progression remains controversial …
[HTML][HTML] The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system
In Alzheimer disease (AD), deposition of neurofibrillary tangles and loss of synapses in the
neocortex and limbic system each correlate strongly with cognitive impairment. Tangles are …
neocortex and limbic system each correlate strongly with cognitive impairment. Tangles are …