The “leaky gut”: tight junctions but loose associations?
D Hollander, JD Kaunitz - Digestive diseases and sciences, 2020 - Springer
The concept of the “leaky gut” has received increasing attention in the lay press and also in
the scientific literature of late due to its associations with numerous gastrointestinal (GI) and …
the scientific literature of late due to its associations with numerous gastrointestinal (GI) and …
The role of intestinal oxalate transport in hyperoxaluria and the formation of kidney stones in animals and man
JM Whittamore, M Hatch - Urolithiasis, 2017 - Springer
The intestine exerts a considerable influence over urinary oxalate in two ways, through the
absorption of dietary oxalate and by serving as an adaptive extra-renal pathway for …
absorption of dietary oxalate and by serving as an adaptive extra-renal pathway for …
Slc26a3 (DRA) in the gut: expression, function, regulation, role in infectious diarrhea and inflammatory bowel disease
Q Yu - Inflammatory Bowel Diseases, 2021 - academic.oup.com
Background The transport of transepithelial Cl-and HCO3-is crucial for the function of the
intestinal epithelium and maintains the acid-based homeostasis. Slc26a3 (DRA), as a key …
intestinal epithelium and maintains the acid-based homeostasis. Slc26a3 (DRA), as a key …
Slc26a3 deficiency is associated with loss of colonic HCO3− secretion, absence of a firm mucus layer and barrier impairment in mice
F Xiao, Q Yu, J Li, MEV Johansson, AK Singh… - Acta …, 2014 - Wiley Online Library
Aim Downregulated in adenoma (DRA, Slc26a3) is a member of the solute carrier family 26
(SLC 26), family of anion transporters, which is mutated in familial chloride‐losing diarrhoea …
(SLC 26), family of anion transporters, which is mutated in familial chloride‐losing diarrhoea …
Loss of Slc26a9 anion transporter alters intestinal electrolyte and HCO3 - transport and reduces survival in CFTR-deficient mice
X Liu, T Li, B Riederer, H Lenzen, L Ludolph… - … -European Journal of …, 2015 - Springer
Slc26a9 is an anion transporter that is strongly expressed in the stomach and lung. Slc26a9
variants were recently found associated with a higher incidence of meconium ileus in cystic …
variants were recently found associated with a higher incidence of meconium ileus in cystic …
Role of the SLC26A9 chloride channel as disease modifier and potential therapeutic target in cystic fibrosis
The solute carrier family 26, member 9 (SLC26A9) is an epithelial chloride channel that is
expressed in several organs affected in patients with cystic fibrosis (CF) including the lungs …
expressed in several organs affected in patients with cystic fibrosis (CF) including the lungs …
Importance of SLC26 transmembrane anion exchangers in sperm post-testicular maturation and fertilization potential
A Touré - Frontiers in Cell and Developmental Biology, 2019 - frontiersin.org
In mammals, sperm cells produced within the testis are structurally differentiated but remain
immotile and are unable to fertilize the oocyte unless they undergo a series of maturation …
immotile and are unable to fertilize the oocyte unless they undergo a series of maturation …
The distinct roles of anion transporters Slc26a3 (DRA) and Slc26a6 (PAT-1) in fluid and electrolyte absorption in the murine small intestine
W Xia, Q Yu, B Riederer, AK Singh… - … -European Journal of …, 2014 - Springer
The mixing of gastric and pancreatic juice subjects the jejunum to unique ionic conditions
with high luminal CO 2 tension and HCO 3− concentration. We investigated the role of the …
with high luminal CO 2 tension and HCO 3− concentration. We investigated the role of the …
Slc26a3 deletion alters pH‐microclimate, mucin biosynthesis, microbiome composition and increases the TNFα expression in murine colon
A Kini, AK Singh, B Riederer, I Yang, X Tan… - Acta …, 2020 - Wiley Online Library
Abstract Aim SLC26A3 (DRA) mediates the absorption of luminal Cl− in exchange for
HCO3− in the distal intestine. Its expression is lost in congenital chloride diarrhoea (CLD) …
HCO3− in the distal intestine. Its expression is lost in congenital chloride diarrhoea (CLD) …
SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion
The severity of intestinal disease associated with Cystic Fibrosis (CF) is variable in the
patient population and this variability is partially conferred by the influence of modifier …
patient population and this variability is partially conferred by the influence of modifier …