Heat shock proteins: agents of cancer development and therapeutic targets in anti-cancer therapy

CW Yun, HJ Kim, JH Lim, SH Lee - Cells, 2019 - mdpi.com
Heat shock proteins (HSPs) constitute a large family of molecular chaperones classified by
their molecular weights, and they include HSP27, HSP40, HSP60, HSP70, and HSP90 …

[HTML][HTML] Harnessing mitochondrial metabolism and drug resistance in non-small cell lung cancer and beyond by blocking heat-shock proteins

B Parma, H Wurdak, P Ceppi - Drug Resistance Updates, 2022 - Elsevier
Lung cancer is the leading cause of cancer-related deaths worldwide, with non-small cell
lung cancer (NSCLC) being the predominant histological subtype. Despite the emergence of …

The role of heat shock proteins in metastatic colorectal cancer: A review

H Javid, P Hashemian, S Yazdani… - Journal of Cellular …, 2022 - Wiley Online Library
Heat shock proteins (HSPs) are a large molecular chaperone family classified by their
molecular weights, including HSP27, HSP40, HSP60, HSP70, HSP90, and HSP110. HSPs …

Role of IQGAP1 in Carcinogenesis

T Wei, PF Lambert - Cancers, 2021 - mdpi.com
Simple Summary IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a signal
scaffolding protein that regulates a range of cellular activities by facilitating signal …

Multi-faceted roles of DNAJB protein in cancer metastasis and clinical implications

HY Kim, S Hong - International Journal of Molecular Sciences, 2022 - mdpi.com
Heat shock proteins (HSPs) are highly conserved molecular chaperones with diverse
cellular activities, including protein folding, assembly or disassembly of protein complexes …

DNAJB6 promotes ferroptosis in esophageal squamous cell carcinoma

B Jiang, YQ Zhao, MO Shi, L Song, Q Wang… - Digestive Diseases and …, 2020 - Springer
Abstract Background DnaJ/Hsp40 homolog, subfamily B, member 6 (DNAJB6) is
significantly down-regulated in esophageal squamous cell carcinoma (ESCC), while its …

DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer

Z Wang, Y Li, R Mao, Y Zhang, J Wen, Q Liu… - Cell Death & …, 2022 - nature.com
Chemotherapy is one of the most frequently used therapies for the treatment of colon cancer
(COAD). However, Oxaliplatin (L-OHP) resistance is a major obstacle to the effective …

[HTML][HTML] The interplay between IQGAP1 and small GTPases in cancer metastasis

X Peng, T Wang, H Gao, X Yue, W Bian, J Mei… - Biomedicine & …, 2021 - Elsevier
The metastatic spread of tumor cells to distant anatomical locations is a critical cause for
disease progression and leads to more than 90% of cancer-related deaths. IQ motif …

Whole genome sequencing reveals complexity in both HPV sequences present and HPV integrations in HPV-positive oropharyngeal squamous cell carcinomas

G Gao, J Wang, JL Kasperbauer, NM Tombers, F Teng… - BMC cancer, 2019 - Springer
Background High risk human papillomaviruses (HPV) plays important roles in the
development of cervical cancer, a number of other anogenital cancer and they are …

Network-based analysis of oligodendrogliomas predicts novel cancer gene candidates within the region of the 1p/19q co-deletion

J Gladitz, B Klink, M Seifert - Acta neuropathologica communications, 2018 - Springer
Oligodendrogliomas are primary human brain tumors with a characteristic 1p/19q co-
deletion of important prognostic relevance, but little is known about the pathology of this …