The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Congenital anomalies of the kidney and urinary tract (CAKUT) refer to a spectrum of
structural renal malformations and are the leading cause of end-stage renal disease in …

Congenital anomalies of the kidney and urinary tract (CAKUT) are a major cause of pediatric
kidney failure. We performed a genome-wide analysis of copy number variants (CNVs) in …

With hundreds of epigenomic maps, the opportunity arises to exploit the correlated nature of
epigenetic signals, across both marks and samples, for large-scale prediction of additional …

Background Congenital anomalies of the kidney and urinary tract (CAKUT) are the most
prevalent cause of kidney disease in the first three decades of life. Previous gene panel …

Urogenital system development in mammals requires the coordinated differentiation of two
distinct tissues, the ductal epithelium and the nephrogenic mesenchyme, both derived from …

BMP-7/OP-1, a member of the transforming growth factor-beta (TGF-beta) family of secreted
growth factors, is expressed during mouse embryogenesis in a pattern suggesting potential …

Auditory-pigmentary syndromes are caused by physical absence of melanocytes from the
skin, hair, eyes, or the stria vascularis of the cochlea. Dominantly inherited examples with …

▪ Abstract This review provides a synthesis that combines data from classical
experimentation and recent advances in our understanding of early eye development …

Rieger syndrome (REG) is an autosomal–dominant human disorder that includes anomalies
of the anterior chamber of the eye, dental hypoplasia and a protuberant umbilicus. We report …