Objective Cardiovascular reactivity is hypothesized to mediate the relationship between
stress and cardiovascular disease. We describe three considerations that are crucial for a …

Blood pressure is a quantitative trait that has a strong genetic component in humans and
rats. Several selectively bred strains of rats with divergent blood pressures serve as an …

Prospective studies on physical activity in relation to the risk for hypertension are scant,
particularly in women. This study aimed at finding out whether regular physical activity can …

During the past five years, the Rat Genome Project has been rapidly gaining momentum,
especially since the announcement in August 2000 of plans to sequence the rat genome …

We developed a new model to examine the role of arterial baroreceptors in the long-term
control of mean arterial pressure (MAP) in dogs. Baroreceptors in the aortic arch and one …

Over the last decade, it has become increasingly apparent that the cause of preterm birth is
multifactorial, involving both genetic and environmental factors. With the development of …

Consomic rats (SS. BN13), in which chromosome 13 from normotensive inbred Brown
Norway rats from a colony maintained at the Medical College of Wisconsin (BN/Mcw) was …

Models of human disease have long been used to understand the basic pathophysiology of
disease and to facilitate the discovery of new therapeutics. However, as long as models …

Immune cells have been implicated in the pathogenesis of hypertension. We hypothesized
that under the influence of chromosome (chr) 2, T lymphocytes contribute to vascular …

Genetic polymorphisms of the renin-angiotensin-aldosterone system in end-stage renal
disease. Background Hypertension contributes to the progression to renal failure. A genetic …