Disruption of susceptibility (S) genes in crops is an attractive breeding strategy for conferring
disease resistance,. However, S genes are implicated in many essential biological functions …

During the last decade, high-throughput sequencing efforts in the fields of transcriptomics
and epigenomics have shed light on the noncoding part of the transcriptome and its …

Mapping chromatin loops from noisy Hi-C heatmaps remains a major challenge. Here we
present DeepLoop, which performs rigorous bias correction followed by deep-learning …

The functional engagement between an enhancer and its target promoter ensures precise
gene transcription. Understanding the basis of promoter choice by enhancers has important …

Developmental gene expression is often controlled by distal regulatory DNA elements called
enhancers. Distant enhancer action is restricted to structural chromosomal domains that are …

Summary Polycomb repressive complex 2 (PRC2) mediates H3K27me3 deposition, which is
thought to recruit canonical PRC1 (cPRC1) via chromodomain-containing CBX proteins to …

During self-renewal, cell-type-defining features are drastically perturbed in mitosis and must
be faithfully reestablished upon G1 entry, a process that remains largely elusive. Here, we …

Extrachromosomal DNA (ecDNA), first described in the 1960s, is emerging as a prevalent
but poorly characterized oncogenic alteration in cancer. ecDNA is a reservoir for oncogene …

Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that
give rise to three essential lineages: the trophectoderm, the epiblast and the primitive …

Chromosome-wide late replication is an enigmatic hallmark of the inactive X chromosome
(Xi). How it is established and what it represents remains obscure. By single-cell DNA …