Mas-related G-protein coupled receptor member X2 (MRGPRX2) is a class A GPCR
expressed on mast cells. Mast cells are granulated tissue-resident cells known for host cell …

Glycine is a non-essential amino acid with many functions and effects. Glycine can bind to
specific receptors and transporters that are expressed in many types of cells throughout an …

GPR18 is a G-protein-coupled receptor that belongs to the orphan class A family. Even
though it shares low sequence homology with the cannabinoid receptors CB1R and CB2R …

G protein-coupled receptors (GPCRs) are key regulatory proteins of immune cell function
inducing signaling in response to extracellular (pathogenic) stimuli. Although unrelated …

The neural functions of adropin, a secreted peptide highly expressed in the brain, have not
been investigated. In humans, adropin is highly expressed in astrocytes and peaks during …

Since the discovery of medium-chain fatty acids as GPR84 ligands, significant
advancements have been made in the development of GPR84 agonists and antagonists …

Anaphylactoid shock is a fatal hypersensitivity response caused by non-IgE mediated mast
cell activation. These reactions are mediated by a family of G protein-coupled receptors …

To investigate the specific genomic features and mutation pattern, whole and near-complete
SARS-CoV-2 genome sequences were analyzed. Clinical samples were collected from 18 …

The ongoing coronavirus pandemic has been a burden on the worldwide population, with
mass fatalities and devastating socioeconomic consequences. It has particularly drawn …

The patent literature is a potentially valuable source of bioactivity data. In this article we
describe a process to prioritise 3.7 million life science relevant patents obtained from the …