Pathophysiology, etiology, epidemiology of type 1 diabetes and computational approaches for immune targets and therapy

B Dariya, G Chalikonda, G Srivani… - Critical Reviews™ in …, 2019 - dl.begellhouse.com
Autoimmune diseases occur when the body's natural defense system fails to differentiate its
own cells from the foreign cells and mistakenly attacks the healthy cells. Among the …

[PDF][PDF] Integrative system biology and mathematical modeling of genetic networks identifies shared biomarkers for obesity and diabetes

AIH Bima, AZ Elsamanoudy, WF Albaqami… - Mathematical …, 2022 - researchgate.net
Obesity and type 2 and diabetes mellitus (T2D) are two dual epidemics whose shared
genetic pathological mechanisms are still far from being fully understood. Therefore, this …

[PDF][PDF] A review on bio informatics for diabetic mellitus

U Makheswari, D Sudarsanam - Int J Pharm Sci Res, 2012 - Citeseer
Diabetes is a metabolic disorder that occurs when the pancreas does not produce enough
insulin or when the body cannot effectively use the insulin it produces. It is classified in to …

Identification and characterization of a small molecule that activates thiosulfate sulfurtransferase and stimulates mitochondrial respiration

ZM Al‐Dahmani, M Hadian, AJ Ruiz‐Moreno… - Protein …, 2023 - Wiley Online Library
The enzyme Thiosulfate sulfurtransferase (TST, EC 2.8. 1.1), is a positive genetic predictor of
diabetes type 2 and obesity. As increased TST activity protects against the development of …

[HTML][HTML] Target and candidate agents for diabetes treatment in the framework of the food nexus

D Abirami, R Gomathi - Energy Nexus, 2022 - Elsevier
Diabetes mellitus is a chronic disease affected by scarcity in the production of insulin. In the
present study, we used the bioinformatics approach to examine the possible inhibitory …

Assessment The effect of WFS1 gene rs734312 G/A variant with type 2 diabetes in Iraqi Arab patients

AJ Hussein, SK Ali - Human Gene, 2023 - Elsevier
Type 2 diabetes mellitus (T2DM) is a chronic metabolic condition characterized by high
blood glucose levels. Mutations in the WFS1 gene cause b-cell death, leading to Wolfram …

Comparative analysis of genes associated with obesity in humans using bioinformatic data and tools

ZS Musliji, AK Pollozhani, K Lisichkov… - Balkan Journal of …, 2021 - sciendo.com
Materials and methods The data for the sequences of the four genes (and corresponding
proteins) have been extracted from the National Center for Biotechnology Information …

Innovative high throughput medicinal chemistry

M Hadian - 2023 - research.rug.nl
Medicinal Chemistry is the science of the discovery and design of new therapeutic
chemicals and their progress into applicable medicines. Medicinal chemistry may involve …

[图书][B] Altered Heparan Sulfate in Ageing and Dementia: A Potential Axis for the Dysregulation of Bace-1 in Alzheimer's Disease

HE Clarke - 2017 - search.proquest.com
Alzheimer's disease (AD) is characterised by amyloid plaques composed of amyloid-beta
(Aß), the cleavage product of the amyloid precursor protein (APP) by the protease beta …

[PDF][PDF] Characterization of a Novel compound that Activates Thiosulfate Sulfurtransferase and Stimulates Mitochondrial Respiration

ZM Al-Dahmani - Discovery of a small molecule allosteric activator …, 2022 - research.rug.nl
Abstract The enzyme Thiosulfate Sulfurtransferase (TST, EC 2.8. 1.1), is a positive genetic
predictor of diabetes type 2 and obesity. As increased TST activity protects against the …