Extracellular vesicles in viral infections: two sides of the same coin?

ST Martins, LR Alves - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
Extracellular vesicles are small membrane structures containing proteins and nucleic acids
that are gaining a lot of attention lately. They are produced by most cells and can be …

HIV-1 latency and viral reservoirs: existing reversal approaches and potential technologies, targets, and pathways involved in HIV latency studies

S Khanal, M Schank, M El Gazzar, JP Moorman… - Cells, 2021 - mdpi.com
Eradication of latent human immunodeficiency virus (HIV) infection is a global health
challenge. Reactivation of HIV latency and killing of virus-infected cells, the so-called “kick …

CounterAKTing HIV: toward a “block and clear” strategy?

S Pasquereau, G Herbein - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
The protein kinase B or Akt is a central regulator of survival, metabolism, growth and
proliferation of the cells and is known to be targeted by various viral pathogens, including …

The role of extracellular vesicles in COVID-19 pathology

ASC Tahyra, RT Calado, F Almeida - Cells, 2022 - mdpi.com
Extracellular vesicles (EVs) have become a trending topic in recent years; they constitute a
new intercellular communication paradigm. Extracellular vesicles are 30–4000 nanometers …

Role of macrophages in HIV pathogenesis and cure: NIH perspectives

J Joseph, W Daley, D Lawrence… - Journal of Leukocyte …, 2022 - academic.oup.com
Macrophages play a significant role in HIV infection and contribute to pathogenesis of
comorbidities as well as establishment of the viral reservoir in people living with HIV. While …

Next-generation proteomics of serum extracellular vesicles combined with single-cell RNA sequencing identifies MACROH2A1 associated with refractory COVID-19

T Kawasaki, Y Takeda, R Edahiro, Y Shirai… - Inflammation and …, 2022 - Springer
Background The coronavirus disease 2019 (COVID-19) pandemic is widespread; however,
accurate predictors of refractory cases have not yet been established. Circulating …

Occludin: a gatekeeper of brain Infection by HIV-1

S Torices, L Daire, S Simon, O Naranjo… - Fluids and Barriers of …, 2023 - Springer
Compromised structure and function of the blood-brain barrier (BBB) is one of the
pathological hallmarks of brain infection by HIV-1. BBB damage during HIV-1 infection has …

Extracellular vesicles in HTLV-1 communication: the story of an invisible messenger

S Al Sharif, DO Pinto, GA Mensah, F Dehbandi… - Viruses, 2020 - mdpi.com
Human T-cell lymphotropic virus type 1 (HTLV-1) infects 5–10 million people worldwide and
is the causative agent of adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated …

Methamphetamine induces the release of proadhesive extracellular vesicles and promotes syncytia formation: a potential role in HIV-1 neuropathogenesis

S Chand, C DeMarino, A Gowen, M Cowen, S Al-Sharif… - Viruses, 2022 - mdpi.com
Despite the success of combinational antiretroviral therapy (cART), the high pervasiveness
of human immunodeficiency virus-1 (HIV)-associated neurocognitive disorders (HAND) …

Extracellular vesicles as a new promising therapy in HIV infection

MA Navarrete-Muñoz, C Llorens, JM Benito… - Frontiers in …, 2022 - frontiersin.org
Combination antiretroviral therapy (cART) effectively blocks HIV replication but cannot
completely eliminate HIV from the body mainly due to establishment of a viral reservoir. To …