Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …

TDP-43 can form pathological proteinaceous aggregates linked to ALS and FTLD. Within the
putative aggregation domain, engineered repeats of residues 341–366 can recruit …

The self-assembly of peptides and proteins into β-sheet rich amyloid fibrils is linked to both
functional and pathological states. In this study, the growth of fibrillar structures of the short …

The primary nucleation step in amyloid fibril formation can, depending on the nature of
peptide sequence, occur in one step, straight from a dilute solution, or in multiple steps, via …

Abstract We investigated the Central Nervous System (CNS) and skeletal muscle tissue from
A woman was clinically diagnosed with amyotrophic lateral sclerosis (ALS) at the age of 22 …

Amyloid-related diseases are characterized by protein conformational change and amyloid
fibril deposition. Metal complexes are potential inhibitors of amyloidosis. Nitrogen …

Deposition of amyloid fibrils is the seminal event in the pathogenesis of numerous
neurodegenerative diseases. The formation of this amyloid assembly is the manifestation of …

Amyloid fibril formation is believed to be a nucleation-controlled process. Depending on the
nature of peptide sequence, fibril nucleation can occur in one step, straight from a dilute …

Metal complexes can effectively inhibit the aggregation of amyloid peptides, such as Aβ,
human islet amyloid polypeptide, and prion neuropeptide PrP106–126. Gold (Au) …

Ruthenium complexes are potential anticancer metallodrugs and inhibitors of various
proteins, such as enzymes and even amyloid peptides. Studies on Aβ protein, human islet …