Host defense peptide mimicking antimicrobial amino acid polymers and beyond: Design, synthesis and biomedical applications

Y Wu, K Chen, J Wang, M Chen, Y Chen, Y She… - Progress in Polymer …, 2023 - Elsevier
Microbial infections endanger human health and life. Conventional antibiotics has saved
countless human lives, however, is seriously challenged by the quick emergence of …

[HTML][HTML] Advances in the antimicrobial treatment of osteomyelitis

C Zhong, Y Wu, H Lin, R Liu - Composites Part B: Engineering, 2023 - Elsevier
Osteomyelitis is a major complication of orthopedic diseases with high recurrence and
morbidity, along with long hospital stays and high medical costs. The conventional treatment …

Transformation of arginine into zero-dimensional nanomaterial endows the material with antibacterial and osteoinductive activity

J Li, J Ma, H Sun, M Yu, H Wang, Q Meng, Z Li… - Science …, 2023 - science.org
Implant-associated infection is a major threat affecting the success of orthopedic surgeries.
Although various materials scavenge bacteria by generating reactive oxygen species (ROS) …

Flexible modulation of cellular activities with cationic photosensitizers: insights of alkyl chain length on reactive oxygen species antimicrobial mechanisms

L Zheng, Y Zhu, Y Sun, S Xia, S Duan, B Yu… - Advanced …, 2023 - Wiley Online Library
Cationic photosensitizers have good binding ability with negatively charged bacteria and
fungi, exhibiting broad applications potential in antimicrobial photodynamic therapy (aPDT) …

Identification of unique indolylcyanoethylenyl sulfonylanilines as novel structural scaffolds of potential antibacterial agents

XM Zhou, QY Li, X Lu, RRY Bheemanaboina… - European Journal of …, 2023 - Elsevier
The increasing incidence of antibiotic resistance has forced the development of unique
antimicrobials with novel multitargeting mechanisms to combat infectious diseases caused …

Benzenesulfonyl thiazoloimines as unique multitargeting antibacterial agents towards Enterococcus faecalis

XM Zhou, YY Hu, B Fang, CH Zhou - European Journal of Medicinal …, 2023 - Elsevier
New efficient antimicrobial agents are urgently needed to combat invasive multidrug-
resistant pathogens infections. Structurally unique benzenesulfonyl thiazoloimines (BSTIs) …

The future of poly (2-oxazoline) s

R Hoogenboom - European Polymer Journal, 2022 - Elsevier
Abstract Poly (2-oxazoline) s have gained significant interest in the past decade, especially
driven by their high potential for biomedical applications, amongst others to substitute poly …

A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens

M Zhou, L Liu, Z Cong, W Jiang, X Xiao, J Xie… - Nature …, 2024 - nature.com
Drug-resistant fungal infections pose a significant threat to human health. Dual-targeting
compounds, which have multiple targets on a single pathogen, offer an effective approach to …

Benzoxazine monomers with antibacterial property and polybenzoxazines for preventing adhesion to bacteria

X Yuan, X Su, Y Wang, L Liu, R Li… - ACS Applied Polymer …, 2023 - ACS Publications
A series of biobased benzoxazine monomers (TF-BOZs) were designed and synthesized
using tyrosine methyl ester, furfural, and five amine sources through the Mannich …

Peptide-mimicking poly (2-oxazoline) s possessing potent antifungal activity and BBB penetrating property to treat invasive infections and meningitis

W Jiang, M Zhou, S Chen, J Xie, M Chen… - Journal of the …, 2023 - ACS Publications
Invasive fungal infections, including meningitis, cause a high mortality rate due to few
available antifungal drugs and frequently associated side effects and quick emergence of …