Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism

P Lindholm, M Saarma - Molecular psychiatry, 2022 - nature.com
Midbrain dopamine neurons deteriorate in Parkinson's disease (PD) that is a progressive
neurodegenerative movement disorder. No cure is available that would stop the …

CDNF and ER stress: Pharmacology and therapeutic possibilities

H Lõhelaid, M Saarma, M Airavaara - Pharmacology & Therapeutics, 2024 - Elsevier
Cerebral dopamine neurotrophic factor (CDNF) is an endogenous protein in humans and
other vertebrates, and it has been shown to have protective and restorative effects on cells in …

Mesencephalic astrocyte-derived neurotrophic factor (MANF): structure, functions and therapeutic potential

YY Liu, D Huo, LT Zeng, GQ Fan, T Shen… - Ageing research …, 2022 - Elsevier
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a novel evolutionarily
conserved protein present in both vertebrate and invertebrate species. MANF shows distinct …

Molecularly imprinted polymer-based SAW sensor for label-free detection of cerebral dopamine neurotrophic factor protein

A Kidakova, R Boroznjak, J Reut, A Öpik… - Sensors and Actuators B …, 2020 - Elsevier
In this study we report on a surface acoustic wave (SAW) sensor modified with a molecularly
imprinted polymer (MIP) film that selectively recognizes the cerebral dopamine neurotrophic …

Trophic activities of endoplasmic reticulum proteins CDNF and MANF

M Jӓntti, BK Harvey - Cell and tissue research, 2020 - Springer
Mesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine
neurotrophic factor (CDNF) are endoplasmic reticulum (ER) luminal proteins that confer …

Serum levels of interleukin-33 and mesencephalic astrocyte derived neurotrophic factors in patients with major depressive disorder: a cross-sectional comparative …

Z Nahar, DT Nowshin, ASM Roknuzzaman, M Sohan… - BMC psychiatry, 2024 - Springer
Background Major depressive disorder (MDD) is a debilitating health condition that has
significant morbidity and mortality rates. Depression can be caused due to social, biological …

UPR Responsive Genes Manf and Xbp1 in Stroke

H Lõhelaid, JE Anttila, HK Liew, KY Tseng… - Frontiers in Cellular …, 2022 - frontiersin.org
Stroke is a devastating medical condition with no treatment to hasten recovery. Its abrupt
nature results in cataclysmic changes in the affected tissues. Resident cells fail to cope with …

[HTML][HTML] Mesencephalic astrocyte-derived neurotrophic factor (MANF) prevents the neuroinflammation induced dopaminergic neurodegeneration

JX Zhang, KG Zhou, YX Yin, LJ Jin, WF Tong… - Experimental …, 2023 - Elsevier
Background The excessive activation of the microglia leads to the release of inflammatory
factors that contribute to neuronal cell loss and neurodegeneration in Parkinson's Disease …

Biomarkers of Parkinson's disease in perspective of early diagnosis and translation of neurotrophic therapies

RK Tuominen, JM Renko - Basic & Clinical Pharmacology & …, 2024 - Wiley Online Library
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
progressive loss of dopamine neurons and aberrant deposits of alpha‐synuclein (α‐syn) in …

CDNF and MANF in the brain dopamine system and their potential as treatment for Parkinson's disease

E Pakarinen, P Lindholm - Frontiers in psychiatry, 2023 - frontiersin.org
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by
gradual loss of midbrain dopamine neurons, leading to impaired motor function. Preclinical …