Safety assessment of drug impurities for patient safety: a comprehensive review

F Liu - Regulatory Toxicology and Pharmacology, 2024 - Elsevier
Drug impurities are undesirable but unavoidable chemicals which can occur throughout the
drug life cycle. The safety implications of drug impurities can be significant given that they …

[PDF][PDF] Importance of drug excipient compatibility studies by using or utilizing or employing various analytical techniques–an overview

R Rajesh, V Navya, SK Kumar - Int J Pharm Sci & Res, 2022 - researchgate.net
The interaction/incompatibility of drug excipients is a major concern in formulation
generation. Compatibility tests for drug excipients constitute an important step of the …

[HTML][HTML] Development of Personalised Immediate-Release Gel-Based Formulations Using Semi-Solid Extrusion

M Aina, F Baillon, R Sescousse, NM Sanchez-Ballester… - Gels, 2024 - mdpi.com
Precision in dosing is crucial for optimizing therapeutic outcomes and preventing
overdosing, especially in preterm infants. Traditional manual adjustments to adapt the dose …

A Computational Approach for Exploring Indinavir as a Potent Protease Inhibitor and Development of Its Microsphere for Anticancer Activity

PK Mohapatra, R Srivastava, KK Varshney… - Journal of …, 2023 - Springer
Purpose The objective of the present investigation was to establish a molecular association
of different proteases as cancer targets with the indinavir and how the physicochemical …

[HTML][HTML] Design, Manufacturing, Characterization and Evaluation of Lipid Nanocapsules to Enhance the Biopharmaceutical Properties of Efavirenz

GK Mukubwa, JB Safari, RB Walker, RWM Krause - Pharmaceutics, 2022 - mdpi.com
Despite their incredible contribution to fighting viral infections, antiviral viral resistance is an
increasing concern and often arises due to unfavorable physicochemical and …

Compatibility study of mirtazapine with several excipients used in pharmaceutical dosage forms employing thermal and non-thermal methods

D Circioban, A Ledeți, A Ridichie, T Vlase… - Journal of Thermal …, 2024 - Springer
Mirtazapine is an atypical antidepressant used in the management of insomnia, post-
traumatic stress disorder, anxiety or panic disorder, obsessive–compulsive disorder and …

Preformulation studies of levonorgestrel

A Ridichie, A Ledeţi, L Sbârcea, G Rusu… - Journal of Thermal …, 2024 - Springer
Levonorgestrel, also called the morning-after pill, is a synthetic progestogen presenting
structural similarities with progesterone. It is mostly used for its contraceptive effect in the …

Recent developments in pediatric and geriatric dosage forms

ALSAN Sallam, DM Omari - Novel Formulations and Future Trends, 2024 - Elsevier
Drug products for pediatrics and geriatrics patients are difficult to formulate because these
subgroups of patients differ from adult average patients in terms of drug absorption …

[PDF][PDF] APPROACHES OF DRUG-EXCIPIENTS INTERACTION IN PHARMACEUTICAL DRUG PRODUCT FORMULATION

SK Thakur, R Pal, P Pandey, A Singh, A Chanana… - 2022 - researchgate.net
Drug excipients interaction is essential for the formulation of the formulation of the
pharmaceutical product which work as the preformulating factor of formulation. Excipients …

[PDF][PDF] DRUG EXCIPIENT INTREACTIONS: OVERVIEW OF DRUG DEGRADATION PATHWAYS

B Changvadiya, B Ukawala, MA Gupta… - 2024 - wjpr.s3.ap-south-1.amazonaws.com
Drugs are the substance wich are administered as medicines or drug products and they are
composed of active substance and excipients. in formulation generation, the interaction of …