Glycomic and glycoproteomic analyses involve the characterization of oligosaccharides
(glycans) conjugated to proteins. Glycans are produced through a complicated nontemplate …

Therapeutic monoclonal antibodies (mAbs) are glycoproteins produced by living cell
systems. The glycan moieties attached to the proteins can directly affect protein stability …

Although Western blots are frequently quantified, densitometry is not documented and
appears to be based merely on traditions and guesswork. Confirming previous experience …

A multitude of monoclonal IgG antibodies directed against a variety of therapeutic targets is
currently being developed and produced by biotechnological companies. The biological …

Glycosylation defines the adhesive properties of animal cell surfaces and the surrounding
extracellular environments. Because cells respond to stimuli by altering glycan expression …

In recent years, a growing number of biopharmaceutical proteins have been produced and
are already available, or will be soon available, in the market. These molecules are more …

A sheathless interface making use of a porous tip has been used for coupling capillary
electrophoresis and electrospray ionization mass spectrometry. First, effective flow rates …

Over the last two decades, coupled capillary electrophoresis (CE)–mass spectrometry (MS)
has developed into a generally accepted technique with a wide applicability. A growing …

Capillary electrophoresis coupled to time-of-flight mass spectrometry (CE–TOF-MS) via a
porous tip sheathless electrospray ionization (ESI) interface was studied for the …

This review provides a comprehensive overview of methodological advances and
applications of CE in the analysis and characterization of recombinant therapeutic and …